COMBINED THERAPEUTIC MEDICAL DEVICE AND STEM CELLS FOR REGENERATIVE NANOMEDICINE

doi:10.4066/biomedicalresearch-C2-004

COMBINED THERAPEUTIC MEDICAL DEVICE AND STEM CELLS FOR REGENERATIVE NANOMEDICINE

Joint Event on International Conference on CARDIOLOGY AND CARDIOVASCULAR MEDICINE & International Conference on STEM CELLS AND REGENERATIVE MEDICINE
June 18-19, 2018 | Osaka, Japan

Nadia Benkirane-Jessel

French National Institute of Health and Medical Research, France

Keynote : Biomed Res

DOI: 10.4066/biomedicalresearch-C2-004

Abstract:

In our group we explored a new generation of smart living implants combining not only active therapeutics but also stem cells, as a novel strategy to regenerate stabilized cartilage and avoid prosthesis, by achieving regeneration of its sub-chondral bone foundation, requirement which is failing today in the clinic. A unique nanotechnology strategy is used to entrap, protect, and stabilize therapeutic agents into polymer coatings: nano-reservoirs, covering nano-fibres of implantable nano-fibrous membranes for bone and cartilage regeneration. Upon contact with cells, therapeutic agents become available through enzymatic degradation of the nano-reservoirs. As cells grow, divide, and infiltrate deeper into the porous membrane, they trigger slow and progressive release of therapeutic agents that, in turn, stimulate further cell proliferation. The nano-reservoirs technology enables to reduce the quantities of required therapeutic agent (compared to soaked membranes for instance) thereby reducing costs.

Biography:

Nadia Benkirane is Research director and head of the “Regenerative Nano¬medicine” laboratory, at INSERM. She was leader of “Active Biomaterials and Tissue Engineering” team INSERM 977. She received her PhD. from University Louis Pasteur, France. She joined the IN¬SERM U595 in 2002 as a post-doc, and re¬ceived the diploma to direct the research (HDR) in 2004. Jessel got the permanent position (CR1) in the INSERM 595 laboratory in 2004 and Research Director (DR2) posi¬tion in the INSERM 977 and head of “active Biomaterials and Tissue Engineering team.

Email: nadia.jessel@inserm.fr

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