Biomimetic Endorphin for Wrinkle Lifting in a Daily Cosmetic Remedy

Biomimetic Endorphin for Wrinkle Lifting in a Daily Cosmetic Remedy

7^th World Congress on Cosmetology And Dermatology & Skin Care
March 23-24, 2022 I Webinar

Ritamaria Di Lorenzo

University of Naples Federico II, Italy

Scientific Tracks Abstracts : Dermatol Res Skin Care

Abstract:

Background: Over time there has been an evolution in cosmetics to find substances that can minimize the signs of aging. In this scenario, peptides play an essential role in obtaining a lifted skin face. The most effective substance used as a lifting ally is the botulinum toxin; subsequently, to its discovery, several biomimetic peptides were synthesized to find other valid compounds. The developed SH-Pentapeptide-5 is an endorphin peptide associated with a delivery system based on Conjugated Linoleic Acid (CLA) amidified with Glutathione. This innovative system, tested in vivo compared to placebo through a single-blind clinical trial, carried out the following actions when applied topically on the panelists’ skin face Methods: This innovative system, tested in vivo compared to placebo through a single-blind clinical trial, carried out the following actions when applied topically on the panelists’ skin face 1) Soothing action: the CLA is a precursor of the anti-inflammatory PGE2 that gives an anti-aging effect linked to the micro skin inflammations relief. 2) Damaged skin repair: through interaction with the hemidesmosomes. The in vivo tested peptide causes the disassembly of the hemidesmosome chains favoring cell migration towards damaged skin areas to heal tissue wounds. 3) Botox-like effect for endorphin-like action: the peptide acts on the neuromuscular synaptic junction in the facial muscles, where through interaction with its target, delta-opioid receptor, it determines a hyperpolarizing effect on the presynaptic neuron. This hyperpolarization inhibits the acetylcholine release; in this way, muscle excitability is inhibited. As a result, the mimic muscle relaxes, and the expression lines are less visible.. Results: results show that the Gluthathione- CLA-SHPentapeptide-5 is a promising ally in treating typical aging dysfunctions. It can lift face wrinkles and firm the skin when applied twice a day topically for a month. In contrast with other peptides like the botulinum toxin, this system is not an injective treatment; consequently, it does not cause side effects, and in addition, it can be conveyed in cosmetic formulations without the need for medical intervention. Conclusion: results show that the Gluthathione- CLA-SHPentapeptide-5 is a promising ally in treating typical aging dysfunctions. It can lift face wrinkles and firm the skin when applied twice a day topically for a month. In contrast with other peptides like the botulinum toxin, this system is not an injective treatment; consequently, it does not cause side effects, and in addition, it can be conveyed in cosmetic formulations without the need for medical intervention.
About University:
The University of Naples was established in 1224 and it remains one of the world’s oldest universities to be founded by a head of state after Frederick II, Holy Roman Emperor and King of Sicily, decided to create an educational institution that was not significantly influenced by the Pope. However, it was not until 1987 that the university was renamed Federico II, an acknowledgement of its founder. Today the university consists of three semi-independent divisions - the Division of Science and Technology, the Division of Life Sciences and the Division of Social and Human Sciences – which are responsible for the research and teaching of 13 schools and 82 different departments. Over the years the University of Naples has had several venues but today there are three major campuses, one in central Naples, one in the Fuorigrotta district in the west and one on the hill of Camaldoli in the north, with the latter also hosting the School of Medicine.
References:
1. Dini I, Falanga D, Di Lorenzo R, Tito A, Carotenuto G, Zappelli C, Grumetto L, Sacchi A, Laneri S, Apone F. An Extract from Ficus carica Cell Cultures Works as an Anti-Stress Ingredient for the Skin. Antioxidants. 2021; 10(4):515. https://doi.org/10.3390/ antiox10040515
2. Bocheva G, Slominski RM, Slominski AT. Neuroendocrine Aspects of Skin Aging. Int J Mol Sci. 2019 Jun 7;20(11):2798. doi: 10.3390/ijms20112798. PMID: 31181682; PMCID: PMC6600459.
3. Linder J. The science behind peptides. Plast Surg Nurs. 2012 Apr-Jun;32(2):71-2. doi: 10.1097/PSN.0b013e3182577344. PMID: 22647954.
4. Zhang L, Falla TJ. Cosmeceuticals and peptides. Clin Dermatol. 2009 Sep-Oct;27(5):485-94. doi: 10.1016/j. clindermatol.2009.05.013. PMID: 19695481.
5. Gazitaeva ZI, Drobintseva AO, Chung Y, Polyakova VO, Kvetnoy IM. Cosmeceutical product consisting of biomimetic peptides: antiaging effects in vivo and in vitro. Clin Cosmet Investig Dermatol. 2017 Jan 7;10:11-16. doi: 10.2147/CCID.S97573. PMID: 28123310; PMCID: PMC5234555.
6. Wu Y, Cao K, Zhang W, Zhang G, Zhou M. Protective and Anti-Aging Effects of 5 Cosmeceutical Peptide Mixtures on Hydrogen Peroxide-Induced Premature Senescence in Human Skin Fibroblasts. Skin Pharmacol Physiol. 2021;34(4):194-202. doi: 10.1159/000514496. Epub 2021 Apr 13. PMID: 33849044.
7. Kim J, Kang S, Kwon H, Moon H, Park MC. Dual functional bioactive-peptide, AIMP1-derived peptide (AdP), for anti-aging. J Cosmet Dermatol. 2019 Feb;18(1):251-257. doi: 10.1111/jocd.12671. Epub 2018 Jun 19. PMID: 29921010.
8. Pai VV, Bhandari P, Shukla P. Topical peptides as cosmeceuticals. Indian J Dermatol Venereol Leprol. 2017 Jan-Feb;83(1):9-18. doi: 10.4103/0378-6323.186500. PMID: 27451932.
9. Fields K, Falla TJ, Rodan K, Bush L. Bioactive peptides: signaling the future. J Cosmet Dermatol. 2009 Mar;8(1):8-13. doi: 10.1111/j.1473-2165.2009.00416.x. PMID: 19250159.
10. Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009 Oct;31(5):327-45. doi: 10.1111/j.1468-2494.2009.00490.x. Epub 2009 Jun 30. PMID: 19570099.

Biography:

Dr. Ritamaria Di Lorenzo is a Ph.D. at the R&D Cosmetics Laboratory of the Pharmacy Department at the University of Naples Federico II. Here she develops and conducts efficacy and activity tests for cosmetic products, researches aimed at identifying new APIs to be conveyed in skincare and haircare products. She authors several divulgation articles in Italian technical journals for cosmetic companies. In Spain, she is currently engaged at the DermoCosmetic center of the Institute of Advanced Chemistry of Catalonia, carrying out research projects in hair aging and interracial differences that regulate the different hair permeation of cosmetic treatments

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