+441518081136Anti-Cancer properties of the Foliose lichen, Heterodermia diademata (Taylor) Awasthi against Breast Cancer cell lines
13th World Cancer Congress
February 25-26, 2019 | Paris, France
Jijo Francis
Sacred Heart College, India
Scientific Tracks Abstracts : J Med Oncl Ther
Abstract:
Nature has its own unique ways to solve her problems. Natural products, especially phytochemicals, are becoming an important area of research for drug discovery. Of late, lichens, the consortium between algae and fungi, have drawn a great deal of attention for their exceptional potential for curing various diseases. Despite the advancement of science, cancer treatment is still not satisfactory and effective. It might reasonably be hypothesized that lichens could contribute to cancer treatment by interfering with the development and/ or progression of cancer. In the present study, I explored the anti-growth properties of the foliose lichen, Heterodermia diademata (Taylor) Awasthi, collected from the Western Ghats biodiversity hotspot, India. Preliminary investigation of the cytotoxic potential of H. diademata was conducted on Daltons Lymphoma Ascites (DLA) and Ehrlich’s Ascites Carcinoma (EAC) in Tryphan Blue dye exclusion method. The anti-growth effect was tested in human breast cancer cell line MDAMB- 231 and normal cell line IEC-6 by MTT assay. Cell death modes (apoptosis/necrosis) were morphologically assessed. H. diademata inhibited the growth in a dose dependent manner up to a dose of 5 to 25μg/ml. IC50 in MDA MB-231 was estimated to be 20ug/mL. Whereas in case of IEC6 IC50 was found to be higher than 60 ug/mL indicative of its potent cytotoxicity towards breast cancer cell. These results suggest that H. diademata may induce cell death at very low doses thus establishing its potential as a promising warrior for the crusade against cancer.
Biography:
Jijo Francis is doing his Post Graduation (M.Sc.) in Zoology in Sacred Heart College (Autonomous), Cochin, Kerala, India.
E-mail: jijothattil007@gmail.com
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