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Alzheimer’s risk factors and impact on heart: Role of Propolis, Vinpocetine and Cocoa combination in enhancing the protective power of mental and physical activity in rats
13th World Congress on Dementia and Alzheimer’s Disease
September 16-17, 2019 | Paris, France
Azza A Ali, Hosny A Elewa, Zeinab Alkasaby Zalat, Rehab Werida, Manal Ali Hamouda, Karema Abu-Elfotuh
Al-Azhar University, Egypt; Horus University, Egypt Damanhur University, Egypt Delta for Science and Technology University, Egypt
Posters & Accepted Abstracts : J Clin Psychiatry Cog Psychol
Abstract:
Background: Alzheimer’s disease (AD) is a progressive
disorder that causes brain cells to waste away and die,
memory loss is the key symptom of the disease. Protein
malnutrition (PM) and Social isolation (SI) have strong
correlations with cognitive decline, they precede the onset
of dementia and represent risk factors in AD progression.
Oxidative stress (OS) is also associated with AD progression
and the deleterious effect of SI and PM on the heart, but
mental and physical (M& Ph) activity can provide marked
protection. Propolis (PROP) with its antioxidant ability can
be an effective treatment for slowing down the damage
caused by OS. Vinpocetine (VIN) can improve cerebral
functions and enhance memory, it promotes cerebral
utilization of oxygen and glucose. Cocoa can reduce stress,
depression and promote better memory, the promising
health benefits of cocoa flavonoids have been evidenced
especially in cardiovascular and cerebrovascular disorders.
Objective: Study the correlation between heart-healthy
and AD progression especially under the risk of PM&SI
as well as, evaluate the impact of VIN, PROP and Cocoa
combination in enhancing the power of M&Ph activity
versus progression of AD in Rats.
Methods: Two major groups of rats were used; Normally- fed
(NF) or PM (10% casein diet) group and each contain two
sets; socialized or isolated set. Both sets were subdivided into
4 subgroups; two received saline (normal) and two received
ALCl3, 70mg/kg IP every day (AD model) during the five
weeks of the experiment. One normal and one AD model
subgroups from each set were received orally combination
treatment of PROP (300mg/kg), VIN (20mg/kg) and Cocoa
(24mg/kg) together with weekly exposed to M&Ph activity
using forced swimming and Y-maze tests. Biochemical
parameters (AChE, Aβ, Tau, β-secretase, monoamines,
oxidative stress and inflammatory markers) as well as DNA
fragmentation and brain derived neurotrophic factor (BDNF)
were estimated in the brain together with heart functions
measurements (serum CKMB, PTX-3, Troponin, AST, HDL, LDL
and Cholesterol). Histopathological changes in the heart and
different brain regions were also examined.
Results: The deleterious effects of PM and SI on the heart
were more sever with AD progression as indicated by the
significant increase in serum CKMB, PTX-3, troponin, AST,
LDL and Cholesterol together with the decrease in HDL.
However, the protective effects of PROP, VIN and Cocoa
combination enhanced the protection induced by M&Ph
activity against the risk of PM and SI on heart especially in
AD-associated groups. Histopathological examinations of
the heart and brain confirmed the biochemical ones.
Conclusion: Marked protection against the deleterious effect
of PM and SI on the heart during AD development was induced
by using PROP, VIN and Cocoa combination. Moreover, they
enhanced the protective power of M&Ph activity against
hazards of different risk factors on the heart and brain.
Biography:
Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology from Faculty of Pharmacy, Cairo University, Egypt. Her postdoctoral studies included different scientific aspects especially on neurodegenerative disorders; she also developed research line of behavioral pharmacology in Egypt and participated as Advisory Board Member of the Arab Association for Pharmacy Development and at the Arab International Pharmacy Conference (AIPC 2019). She is member of many scientific societies as (AAPS) and Alzheimer's Association (ISTAART). She is also Editorial Board Member of many international Journals as Brain Disorder & Therapy, Acta Psychopathologica, EC Pharmacology and Toxicology as well as Organizing Committee Member and Chairperson at many international Conferences as the International Conference on Brain Disorders & Dementia Care, Canada (2017) and International Conference on Parkinson's Disease & Movement Disorders, USA (2017, 2018). She published more than 60 papers in reputed journals, supervised and discussed more than 90 PhD and MSc thesis and actively participated by workshop, oral and posters presentations at many international conferences especially on Dementia and Parkinson's disease and in the Alzheimer's Association International Conference (AAIC 2016, 2017). She has many appreciation certificates and certificate of best presentation award at 19th International Conference on Environmental Pollution and Pollution Control, London, UK (ICEPPC 2017). Now she is a Head of Pharmacology and Toxicology Department and Member of the Committee for the Promotion of Professors at Al-Azhar University, Egypt.
E-mail: azzamoro@gmail.com
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