+1 (629)348-3199A study of dopamine D2 receptor Taq1 A alleles in children with attention deficit hyperactivity disorder
Joint Event on International Conference and Exhibition on Probiotics, Nutrition and Functional Foods & 17th World Congress on Pediatrics and Nutrition
July 05-06, 2019 | Paris, France
Marwa Mohammed Moro
Ain Shams University, Egypt
Scientific Tracks Abstracts : J Pub Heath Catalog
Abstract:
Background: Attention deficit hyperactivity disorder (ADHD)
is a common neuro-developmental disorder influenced
by many genes. The Dopamine receptor D2 (DRD2)
Taq1Apolymorphism affects the intracellular concentration
of the second messenger cyclic adenosinemonophosphate
(cAMP). This study aimed to assess the relationship between
Taq1 Apolymorphism and ADHD in a sample of Egyptian
children.
Methodology: DRD2-Taq1A gene polymorphism was evaluated
in 100 participants, 50 ADHD patients and 50 controls of
healthy children with normal developmental and psychiatric
evaluation with comparable age and sex. The patients were
recruited from Psychiatric clinic, Faculty of Postgraduate
Studies for Childhood- Ain Shams University, Cairo, Egypt with
age ranged from 6 to 12 years. RD2-Taq 1A allele distribution
was investigated via polymerase chain reaction (PCR).
Results: Phenotype distributions of A1 allele showed statistically
significant association with ADHD cases compared to controls
(p=0.037). A significant association was found betweenADHD
cases and heterozygous A1A2 genotype (p=0.047). Meanwhile,
ADHD cases showedstatistically significant lower distribution of
the homozygous A2A2 genotype (p=0.027).
Conclusion: There was an evident association between
ADHD phenotype and (DRD2) Taq1Agene polymorphism, and
there was a heterozygous advantage regarding A1A2 allele
genotypeand ADHD cases.
Biography:
Marwa Mohammed Moro graduated from faculty of medicine at Cairo University, Egypt and had her master degree from the same university. She has completed her PHD in January 2019 from Ain Shams University. She is specialist of pediatrics in ministry of health hospitals, Egypt. She has some publications that have been cited several times.
E-mail: sdr_loly5@yahoo.com
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