+1 (629)348-3199A contribution of Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms in children with attention deficit hyperactivity disorder
Joint Event on International Conference and Exhibition on Probiotics, Nutrition and Functional Foods & 17th World Congress on Pediatrics and Nutrition
July 05-06, 2019 | Paris, France
Khaled Ismail AbdElShakoor
Ain Shams University, Egypt
Scientific Tracks Abstracts : J Pub Heath Catalog
Abstract:
Background: Attention Deficit Hyper-Activity Disorder
(ADHD) is a neuro-behavioral, complex disorder influenced
by many genes. The MTHFR gene C677T and A1298C
polymorphisms affect both nucleotide synthesis and DNA
methylation. This study aimed to assess the relationship
between Methylenetetrahydrofolate Reductase (MTHFR)
gene polymorphisms and ADHD in a sample of Egyptian
children.
Methods: MTHFR gene polymorphisms were evaluated
in 60 participants, 30 ADHD patients and 30 controls of
healthy children with normal developmental and psychiatric
evaluation with comparable age and sex. The patients were
recruited from Psychiatric clinic, Faculty of Postgraduate
Studies for Childhood-Ain Shams University, Cairo, Egypt
during the period from January to August 2015 with age
ranged from 6 to 12years. MTHFR C677T and A1298C alleles
distribution was investigated via polymerase chain reaction
(PCR) and reverse hybridization.
Results: The recorded genetic results showed heterozygous
advantage (Heterosis) regarding studied C677T allele
genotype with statistically significant association reported
in controls compared to ADHD cases (p=0.0159). Genotype
distributions of A1298C allele showed statistically high
significant association with ADHD cases compared to controls
(p=0.0002). A significant association was found between
males of ADHD cases and hetero- homozygous A1298C
allele compared to controls (p=0.0079). Meanwhile, ADHD
females showed statistically significant higher distribution
of the hetero- homozygous genotypes compared to controls
(p=0.0072).
Conclusions: There was an evident association between
ADHD phenotype and MTHFR A1298C gene polymorphism,
and there was a heterozygous advantage (Heterosis) regarding
C677T allele genotype and ADHD cases leading to absence of
association between MTHFR C677T gene polymorphism and
ADHD
Biography:
Khaled Ismail AbdElShakoor has completed his PhD in January 2019 from Ain Shams University, Egypt. He is consultant of pediatrics in ministry of health hospitals, Egypt. He has some publications that has been cited several times and has been serving as an editorial board member of reputed medical Journals.
E-mail: khaledprime@hotmail.com
PDF HTML