Asymmetrically designed siRNAs and shRNAs enhance the strand specificity and efficacy in RNAi
Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, USA
Biography:
Hongyan Wang doin Ph.D. in Mol. Genet. at Shanghai Brain Research Institute, Chinese. Birth defects could be induced by folate deficiency and gene mutations. Our lab has been focusing on identifying genetic contributors and the underlying molecular mechanism of how supplemented folate preventing birth defects. With a particular emphasis on genetics analysis strategies fitting to complex disease such as neural tube defects
Subjects of specialization: Gene silencing, RNAi therapy, reverse genetics