Rapid Communication - Journal of Clinical Endocrinology Research (2023) Volume 6, Issue 4

Unravelling the significance of β-c-terminal telopeptide of type 1 collagen

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Department of Regenerative Medicine Research Center, West China Hospital, Sichuan University, Chengdu, China

Corresponding Author:

Department of Regenerative Medicine Research Center,
West China Hospital, Sichuan University, Chengdu, China.
E-mail: fengly310@hotmail.com

Received: 21-Jul-2023, Manuscript No. AAJCER-23-113397; Editor assigned: 24-Jul-2023, PreQC No. AAJCER-23-113397(PQ); Reviewed: 07-Aug-2023, QC No. AAJCER-23-113397; Revised: 09-Aug-2023, Manuscript No. AAJCER-23-113397(R); Published: 16-Aug-2023, DOI:10.35841/aajcer-6.4.163

Citation: Feng L. Unravelling the significance of β-c-terminal telopeptide of type 1 collagen. J Clin Endocrinol Res. 2023;6(4):163

In the intricate tapestry of human biology, collagen emerges as a vital structural protein, playing a key role in maintaining the integrity of tissues, bones, and skin. Within the world of collagen, the β-C-terminal telopeptide of type 1 collagen, often abbreviated as β-CTX, stands as a crucial biomarker. This article aims to explore the significance of β-CTX, its role in bone health, its clinical applications, and its relevance in understanding bone metabolism. Collagen, the most abundant protein in the human body, forms the structural scaffold for our skin, tendons, ligaments, and bones. Within this intricate world of collagen, the β-C-terminal telopeptide of type 1 collagen, often abbreviated as β-CTX, holds a profound significance that goes beyond its molecular structure. β-CTX serves as a crucial biomarker with a fascinating story to tell about bone health, disease diagnosis, and the dynamic processes that govern our skeletal system. In this exploration, we embark on a journey to unravel the mysteries and implications surrounding β-CTX, shedding light on its vital role in the realm of bone metabolism and healthcare.

The basics of β-c-terminal telopeptide of type 1 collagen

β-CTX is a small peptide fragment derived from type 1 collagen, which is the most abundant collagen type in the human body. Type 1 collagen provides tensile strength to bones, tendons, skin, and various connective tissues. Collagen molecules in bone tissue consist of three polypeptide chains, twisted together in a helical structure. These chains have regions at both ends known as telopeptides.

Significance in bone metabolism

β-CTX holds particular importance in the context of bone metabolism. As bones undergo continuous remodeling throughout life, old bone tissue is broken down (resorption), and new bone tissue is formed (formation) to maintain skeletal health. β-CTX is a marker primarily associated with bone resorption. When osteoclasts, specialized cells responsible for breaking down bone tissue, actively engage in their work, they release β-CTX fragments into the bloodstream. Elevated β-CTX levels in blood or urine indicate an increase in bone resorption, which can be indicative of various bone-related conditions.

Clinical applications

Diagnosis of Bone Disorders: β-CTX is utilized as a diagnostic tool to assess bone health and detect bone disorders, such as osteoporosis, osteopenia, and Paget's disease. Elevated β-CTX levels can signal increased bone resorption, which is common in these conditions.

Monitoring Osteoporosis Treatment: Patients undergoing treatment for osteoporosis often have their β-CTX levels monitored. A reduction in β-CTX can indicate the effectiveness of medications designed to inhibit bone resorption and promote bone formation.

Research and Drug Development: Researchers studying bone metabolism and developing therapies for bone disorders use β-CTX measurements to assess the impact of potential treatments and gain insights into bone remodeling processes.

Relevance in overall health

Understanding β-CTX levels is not limited to bone health alone. Bone health is interconnected with overall health, and imbalances in bone metabolism can have wider systemic effects. For instance, excessive bone resorption can lead to calcium release into the bloodstream, affecting mineral balance and potentially contributing to conditions like hypercalcemia.

Conclusion

The β-C-terminal telopeptide of type 1 collagen, or β-CTX, serves as a valuable biomarker in the realm of bone health and metabolism. Its role in indicating bone resorption makes it an essential tool in diagnosing bone disorders, monitoring treatment efficacy, and advancing research in the field of skeletal health. By measuring and understanding β-CTX levels, healthcare professionals can take proactive measures to prevent and manage bone-related conditions, ultimately contributing to the overall well-being of individuals. In the ever-evolving landscape of medical science, β-CTX continues to be a key piece in the puzzle of human health and well-being.

References

1. Shou Z, Jin X, Bian P, et al. Reference intervals of β?C?terminal telopeptide of type I collagen, procollagen type IN?terminal propeptide and osteocalcin for very elderly Chinese men. Geriatr Gerontol Int. 2017;17(5):773-8.

Indexed at, Google Scholar, Cross Ref

2. Delmas PD, Munoz F, Black DM, et al. Effects of yearly zoledronic acid 5 mg on bone turnover markers and relation of PINP with fracture reduction in postmenopausal women with osteoporosis. J Bone Miner Res. 2009;24(9):1544-51.

Indexed at, Google Scholar, Cross Ref

3. Zhang J, Zhou WJ, Zhang YD, et al. Relationship between Body Mass Index and Bone Turnover Markers in Girls with Idiopathic Central Precocious Puberty. Int J Clin Pract. 2023;2023.

Indexed at, Google Scholar, Cross Ref

4. Chester D, Brown AC. The role of biophysical properties of provisional matrix proteins in wound repair. Matrix Biol. 2017;60:124-40.

Indexed at, Google Scholar, Cross Ref

5. Wang B, Cheng X, Fu S, et al. Associations of Serum 25 (OH) D, PTH, and β-CTX Levels with All-Cause Mortality in Chinese Community-Dwelling Centenarians. Nutrients. 2022;15(1):94.

Indexed at, Google Scholar, Cross Ref