Journal of Gastroenterology and Digestive Diseases

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Mini Review - Journal of Gastroenterology and Digestive Diseases (2024) Volume 9, Issue 1

Understanding Acute Kidney Injury: Causes, Symptoms, and Treatment

Annette Ion *

Department of Pediatrics, University of Alberta, Canada

*Corresponding Author:
Annette Ion
Department of Pediatrics, University of Alberta, Canada
E-mail: annette@ualberta.ca

Received: 29-Dec-2023, Manuscript No. JGDD-24-127474; Editor assigned: 03-Jan-2024, PreQC No. JGDD-24-127474(PQ); Reviewed: 15-Jan-2024, QC No. JGDD-24-127474; Revised: 19-Jan-2024, Manuscript No. JGDD-24-127474(R); Published: 25-Jan-2024, DOI:10.35841/jgdd-9.1.181

Citation: : Ion A. Understanding acute kidney injury: Causes, symptoms, and treatment. J Gastroenterol Dig Dis. 2024;9(1):181

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Introduction

Acute Kidney Injury (AKI), formerly known as acute renal failure, is a sudden and often reversible loss of kidney function. It is a serious medical condition that requires prompt diagnosis and treatment to prevent complications and improve outcomes. In this article, we delve into the intricacies of acute kidney injury, exploring its causes, symptoms, diagnosis, and management strategies [1].

The kidneys play a vital role in filtering waste products and excess fluid from the blood, maintaining electrolyte balance, and producing hormones that regulate blood pressure and red blood cell production. When the kidneys suddenly lose their ability to function properly, waste products and fluids accumulate in the body, leading to a cascade of physiological disturbances [2].

Acute kidney injury can occur due to various factors, including: Decreased blood flow to the kidneys (prerenal): This may result from conditions such as dehydration, severe bleeding, heart failure, or shock, leading to inadequate perfusion of the kidneys [3].

Damage to kidney tissue (intrinsic): Causes of intrinsic AKI include acute tubular necrosis (ATN) due to ischemia, nephrotoxic medications (e.g., certain antibiotics, contrast agents), infections, autoimmune diseases, and kidney stones. Obstruction of urinary flow (postrenal): Blockages in the urinary tract, such as urinary stones, tumors, or enlarged prostate, can prevent the flow of urine from the kidneys, leading to AKI [4].

The signs and symptoms of acute kidney injury may vary depending on the underlying cause and severity of kidney damage. Common manifestations include: Decreased urine output (oliguria) or absence of urine production (anuria) [5].

Fluid retention, leading to swelling (edema) in the legs, ankles, or face. Fatigue, weakness, and lethargy. Nausea, vomiting, and loss of appetite Confusion, difficulty concentrating, and seizures (in severe cases) [6].

Diagnosing acute kidney injury involves a thorough evaluation of medical history, physical examination, laboratory tests, and imaging studies. Key diagnostic tests include: Blood tests: Measurement of serum creatinine and blood urea nitrogen (BUN) levels to assess kidney function. Urine tests: Analysis of urine for the presence of blood, protein, and other abnormalities. Imaging studies: Ultrasound, CT scan, or MRI may be performed to visualize the kidneys and urinary tract and identify any structural abnormalities or obstructions [7].

The management of acute kidney injury focuses on addressing the underlying cause, preventing complications, and supporting kidney function. Treatment strategies may include: Fluid resuscitation: Intravenous fluids are administered to optimize blood flow to the kidneys and maintain adequate hydration [8].

Medications: Depending on the cause of AKI, medications to manage blood pressure, correct electrolyte imbalances, and minimize further kidney damage may be prescribed [9].

Dialysis: In severe cases of acute kidney injury, dialysis may be necessary to remove waste products and excess fluid from the blood. Nutritional support: A balanced diet with restricted protein, sodium, and potassium intake may be recommended to alleviate strain on the kidneys and promote recovery [10].

Conclusion

Acute kidney injury is a serious condition that requires prompt recognition and intervention to prevent irreversible kidney damage and improve patient outcomes. By understanding the underlying causes, recognizing the symptoms, and implementing appropriate treatment strategies, healthcare providers can effectively manage AKI and minimize its impact on patient health and well-being. Continued research and advancements in the field of nephrology hold promise for improved diagnostic techniques and therapeutic interventions, ultimately enhancing the care and management of individuals with acute kidney injury.

References

  1. Levine DS, Blount PL, Rudolph RE, et al. Safety of a systematic endoscopic biopsy protocol in patients with Barrett’s esophagus. Am. J. Gastroenterol. 2000;95(5):1152-7.

    2. Indexed at, Google Scholar, Cross Ref

  2. Shiraishi T, Kawahara K, Shirakusa T, et al. Risk analysis in resection of thoracic esophageal cancer in the era of endoscopic surgery. Ann Thorac Surg. 2006;81(3):1083-9.

    3. Indexed at, Google Scholar, Cross Ref

  3. McGee MF, Rosen MJ, Marks J, et al. A primer on natural orifice transluminal endoscopic surgery: building a new paradigm. Surgical innovation. 2006;13(2):86-93.

    4. Indexed at, Google Scholar, Cross Ref

  4. Khattak IU, Kimber C, Kiely EM, et al. Percutaneous endoscopic gastrostomy in paediatric practice: complications and outcome. J. Pediatr. Surg.. 1998;33(1):67-72.

    5. Indexed at, Google Scholar, Cross Ref

  5. Levine DS, Blount PL, Rudolph RE, et al. Safety of a systematic endoscopic biopsy protocol in patients with Barrett’s esophagus. Am. J. Gastroenterol. 2000;95(5):1152-7.

    6. Indexed at, Google Scholar, Cross Ref

  6. Rostami K, Steegers EA, Wong WY, et al. Coeliac disease and reproductive disorders: a neglected association. Eur J Obstet Gynecol.2001;96(2):146-9.

    7. Indexed at, Google Scholar, Cross Ref

  7. Ciacci C, Iavarone A, Mazzacca G, De et al. Depressive symptoms in adult coeliac disease. J. Gastroenterol.1998;33(3):247-50.

    8. Indexed at, Google Scholar, Cross Ref

  8. Murch S, Jenkins H, Auth M, et al. Joint BSPGHAN and Coeliac UK guidelines for the diagnosis and management of coeliac disease in children. Arch Dis Childh Lond. 2013;98(10):806-11.

    9. Indexed at, Google Scholar, Cross Ref

  9. Kneepkens CF, von Blomberg BM. Clinical practice: coeliac disease. Eur. J. Pediatr. 2012;171:1011-21.

    10. Google Scholar

  10. Ascher H, Holm K, Kristiansson B, et al. Different features of coeliac disease in two neighbouring countries. Arch Dis Childh Lond.1993;69(3):375-80.

    11. Indexed at, Google Scholar, Cross Ref

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