Journal of Invasive and Non-Invasive Cardiology

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Rapid Communication - Journal of Invasive and Non-Invasive Cardiology (2023) Volume 6, Issue 3

The multifaceted functions of cardiac fibroblasts in heart physiology

Davis Furtado*

Department of Anesthesiology, Michigan Medicine - University of Michigan, Ann Arbor, USA

*Corresponding Author:
Davis Furtado
Department of Anesthesiology,
Michigan Medicine - University of Michigan
Ann Arbor, USA
E-mail: furtado.davis@med.umich.edu

Received:26-May-2023, Manuscript No. AAINIC-23-99687;Editor assigned: 09-Jun-2023, PreQC No. AAINIC-23-99687(PQ);Reviewed:13-Jun-2023, QC No. AAINIC-23-99687;Revised:23-Jun-2023, Manuscript No. AAINIC-23-99687(R); Published:26-Jun-2023, DOI: 10.35841/aainic-6.3.153

Citation: Furtado D. The multifaceted functions of cardiac fibroblasts in heart physiology. J Invasive Noninvasive Cardiol. 2023;6(3):153

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Introduction

The heart is a complex organ composed of various cell types, each playing a crucial role in its function. Among these cell types are cardiac fibroblasts, which were initially thought to function solely as structural support for the heart. However, recent research has revealed that these cells have multifaceted functions that are essential for heart physiology. Cardiac fibroblasts are the most abundant cell type in the heart, making up approximately two-thirds of its total cell population. They are responsible for maintaining the structural integrity of the heart by producing extracellular matrix (ECM) proteins such as collagen, elastin, and fibronectin. The ECM provides a scaffold for the cardiac muscle cells (cardiomyocytes) and helps to maintain the architecture of the heart. In addition to their structural role, cardiac fibroblasts also play a crucial role in the regulation of cardiac function. They are involved in a range of processes such as inflammation, immune response, angiogenesis, and electrical conduction. Here, we will discuss some of the multifaceted functions of cardiac fibroblasts in heart physiology [1].

One of the most important roles of cardiac fibroblasts is the regulation of the ECM. They produce and maintain the ECM proteins, which provide structural support to the heart. In response to various stimuli such as mechanical stress, inflammation, and injury, cardiac fibroblasts can alter the composition and organization of the ECM. This can lead to pathological remodeling of the heart, which can result in heart failure. Cardiac fibroblasts also play a role in the regulation of cardiac function by secreting various cytokines and growth factors. These molecules can stimulate the proliferation of cardiomyocytes, promote angiogenesis, and modulate inflammation. For example, cardiac fibroblasts can produce transforming growth factor-beta (TGF-β), which is involved in the regulation of ECM remodeling and angiogenesis. TGF-β can also promote the differentiation of fibroblasts into myofibroblasts, which are contractile cells that can contribute to cardiac remodeling [2].

Another important function of cardiac fibroblasts is their involvement in the immune response. They can act as antigenpresenting cells and can produce various cytokines that can modulate immune cell function. For example, cardiac fibroblasts can produce interleukin-6 (IL-6), which is involved in the recruitment of immune cells to the heart. They can also produce chemokines such as monocyte chemoattractant protein-1 (MCP-1), which can attract monocytes and other immune cells to the site of injury [

Cardiac fibroblasts are also involved in angiogenesis, which is the process of new blood vessel formation. This is essential for the delivery of oxygen and nutrients to the heart. Cardiac fibroblasts can produce various growth factors such as vascular endothelial growth factor (VEGF), which can promote angiogenesis. They can also produce Matrix Metalloproteinases (MMPs), which are involved in the degradation of ECM proteins and can facilitate the formation of new blood vessels [4].

Finally, cardiac fibroblasts also play a role in the electrical conduction of the heart. They are involved in the formation and maintenance of the cardiac conduction system, which is responsible for the electrical impulses that regulate heart rate and rhythm. Cardiac fibroblasts can produce connexins, which are proteins that form gap junctions between cells. Gap junctions allow for the rapid transmission of electrical signals between cells, which is essential for the proper functioning of the cardiac conduction system [5].

Conclusion

Cardiac fibroblasts are a multifaceted cell type that plays a crucial role in heart physiology. They are involved in a range of processes such as ECM remodeling, angiogenesis, immune response, cytokine secretion, and electrical conduction. Dysfunction of cardiac fibroblasts can lead to pathological remodeling of the heart, which can result in heart failure. Therefore, understanding the functions of cardiac fibroblasts is essential for the development of new therapies for heart disease. One potential therapeutic approach is the modulation of cardiac fibroblast function. For example, targeting the production of specific cytokines or growth factors could alter the immune response or angiogenesis in the heart. Similarly, modulating the production of ECM proteins could prevent pathological remodeling of the heart. Furthermore, targeting the formation and maintenance of the cardiac conduction system could be a potential approach for the treatment of arrhythmias.

 

References

  1. Gourdie RG, Dimmeler S, Kohl PNovel therapeutic strategies targeting fibroblasts and fibrosis in heart disease. Nat Rev Drug Discov. 2016; 15(9): 620-38

    2. Indexed at, Google Scholar, Cross Ref

  2. Furtado MB, Costa MW, Pranoto EA, et al.Cardiogenic genes expressed in cardiac fibroblasts contribute to heart development and repair. Circul Res. 2014;114(9):1422-34. Circul Res. 2014;114(9):1422-34. Circul Res. 2014;114(9):1422-34.

    3. Indexed at, Google Scholar, Cross Ref

  3. Shinde AV, Frangogiannis NG. Fibroblasts in myocardial infarction: A role in inflammation and repair. Mol Cell Cardiol. 2014;70:74-82.

    4. Indexed at, Google Scholar,

  4. Van Putten S, Shafieyan Y, Hinz B. Mechanical control of cardiac myofibroblasts.. J Mol Cell Cardiol. 2016;93:133-42.

    5. Indexed at, Google Scholar, Cross Ref

  5. Weber KT, Sun Y, Bhattacharya SK, et al.Myofibroblast-mediated mechanisms of pathological remodelling of the heart.. Nat Rev Cardiol. 2013;10(1):15-26.

    6. Indexed at, Google Scholar, Cross Ref

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