Gynecology and Reproductive Endocrinology

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +1 (629)348-3199

Short Communication - Gynecology and Reproductive Endocrinology (2024) Volume 8, Issue 5

The Evolving Landscape of Hormone Replacement Therapy: Benefits, Risks, and Advances in Menopausal Care

Gili Kavakli *

Thrombosis & Haemostasis Unit, Medical University of Vienna, Austria

*Corresponding Author:
Gili Kavakli
Thrombosis & Haemostasis Unit, Medical University of Vienna, Austria
E-mail: kavakli@vu.aut.co

Received: 23-Aug-2024, Manuscript No. AAGGS-24-154862; Editor assigned: 24-Aug-2024, PreQC No. AAGGS-24-154862(PQ); Reviewed: 07-Sep-2024, QC No. AAGGS-24-154862Revised: 12-Sep-2024, Manuscript No. AAGGS-24-154862(R); Published: 19-Sep-2024, DOI: 10.35841/aajnnr-8.5.227

Citation: : Kavakli G. The evolving landscape of hormone replacement therapy: Benefits, risks, and advances in menopausal care. Gynecol Reprod Endocrinol.2024;8(5):227

Visit for more related articles at Gynecology and Reproductive Endocrinology

Introduction

Hormone replacement therapy (HRT) has been a cornerstone of menopausal care for decades, offering relief from symptoms such as hot flashes, night sweats, and vaginal dryness [1]. The therapy involves supplementing the body with estrogen, progesterone, or a combination of both to restore hormonal balance after menopause [2]. HRT has been shown to improve quality of life, prevent bone loss, and reduce the risk of osteoporosis [3]. Studies have also suggested that it can provide cardiovascular benefits if started early in menopause, by improving lipid profiles and enhancing arterial health [4].

The use of HRT is not without risks [5]. Long-term use of combined estrogen-progestin therapy has been associated with an increased risk of breast cancer, stroke, and deep vein thrombosis (VTE) [6]. These risks prompted a reevaluation of HRT in the early 2000s, leading to more cautious prescribing practices [7].

In recent years, advances in HRT formulations and delivery methods have improved the safety and efficacy of treatment [8]. Transdermal patches, gels, and low-dose oral preparations are now available, offering more targeted approaches with fewer side effects [9]. Bioidentical hormone therapy, which uses hormones that are chemically identical to those produced by the body, has also gained popularity, although its safety and efficacy are still being studied [10].

Conclusion

While HRT remains an effective treatment for menopausal symptoms and related health issues, it is important to weigh the benefits against the risks. The evolving landscape of HRT, with advances in formulations and delivery methods, continues to improve patient outcomes. Personalized treatment plans and ongoing monitoring are key to maximizing the benefits of HRT while minimizing its potential risks.

References

  1. Beck KL, Anderson MC, Kirk JK. Transdermal estrogens in the changing landscape of hormone replacement therapy. Postgrad Med. 2017;129(6):632-6.

    2. Indexed at, Google Scholar, Cross Ref

  2. Pickar JH, Archer DF, Kagan R, et al. Safety and benefit considerations for menopausal hormone therapy. Expert Opin Drug Saf. 2017;16(8):941-54.

    3. Indexed at, Google Scholar, Cross Ref

  3. Briggs P, Barber K, Cooke K, et al. Consensus-led recommendations supporting choice and personalisation of hormone replacement therapy in menopause care. Post Reprod Health. 2022;28(2):71-8.

    4. Indexed at, Google Scholar, Cross Ref

  4. Birkhäuser MH, Birkhäuser MH, Panay N, et al. Updated practical recommendations for hormone replacement therapy in the peri-and postmenopause. Climacteric. 2008;11(2):108-23.

    5. Indexed at, Google Scholar, Cross Ref

  5. Birkhäuser MH, Reinecke I. Current trends in hormone replacement therapy: perceptions and usage. Climacteric. 2008;11(3):192-200.

    6. Indexed at, Google Scholar, Cross Ref

  6. Seelig MS, Altura BM, Altura BT. Benefits and risks of sex hormone replacement in postmenopausal women. J Am Coll Nutr. 2004;23(5):482-96.

    7. Indexed at, Google Scholar, Cross Ref

  7. Pinkerton JA, Aguirre FS, Blake J, et al. The 2017 hormone therapy position statement of the North American Menopause Society. Menopause. 2017:728-53.

    8. Indexed at, Google Scholar, Cross Ref

  8. Simon JA. What's new in hormone replacement therapy: focus on transdermal estradiol and micronized progesterone. Climacteric. 2012;15(1):3-10.

    9. Indexed at, Google Scholar, Cross Ref

  9. Lewis J. Feminism, the menopause and hormone replacement therapy. Fem. Rev. 1993;43(1):38-56.

    10. Google Scholar

  10. Pines A, Sturdee DW, Birkhäuser MH, et al. HRT in the early menopause: scientific evidence and common perceptions. Climacteric. 2008;11(4):267-72.

    11. Indexed at, Google Scholar, Cross Ref

Get the App