Short Communication - Journal of Clinical Endocrinology Research (2021) Volume 4, Issue 1

Systematic aspects associated within cortisol hormone

Leigh Searle*

Department of Obstetrics and Gynecology, University of Otago, Wellington, New Zealand

Corresponding Author:

Leigh Searle
Department of Obstetrics and Gynecology
University of Otago
Wellington, New Zealand
E-mail: leighsearle01@nyu.edu

Accepted date: August 25, 2021

Citation: Searle L. Systematic aspects associated within cortisol hormone. Clin Endocrinol. 2021;4(1):3.

Abstract

Description

Cortisol may be a naturally-occurring steroid that plays a key role within the body's stress response. While it's often called "the stress hormone", it also contributes too many of the body's processes. It's secreted by the adrenal glands and involved within the regulation. Cortisol is usually called the "stress hormone" due to its connection to the strain response and also for its best-known role. However, cortisol is far quite just a hormone released during stress.

Understanding cortisol and its effect on the body will assist you balance your hormones and achieve healthiness. Cortisol is one among the steroid hormones and is formed within the adrenal glands. Most cells within the body have cortisol receptors. Secretion of the hormone is controlled by the hypothalamus, the pituitary, and therefore the adrenal, a mixture glands often mentioned because the HPA axis. One among the glucocorticoids, made within the cortex of the adrenal glands then released into the blood, which transports it all around the body. Almost every cell contains receptors for cortisol and so cortisol can have lots of different actions depending on which sort of cells it is acting upon. These effects include controlling the body’s blood glucose levels and thus regulating metabolism, acting as an anti-inflammatory, influencing memory formation, controlling salt and water balance, influencing vital sign and helping development of the fetus. In many species cortisol is additionally liable for triggering the processes involved in parturition. Blood levels of cortisol vary throughout the day, but generally are higher within the morning once we awaken, then fall throughout the day. This is called a diurnal rhythm. In people that work at night, this pattern is reversed, so the timing of cortisol release is clearly linked to daily activity patterns. In addition, in response to worry, extra cortisol is released to assist the body to reply appropriately. The secretion of cortisol is especially controlled by three intercommunicating regions of the body; the hypothalamus within the brain, the pituitary and therefore the adrenal [1,2].

This is called the hypothalamic pituitary adrenal axis. When cortisol levels within the blood are low, a gaggle of cells during a region of the brain called the hypothalamus releases corticotrophin-releasing hormone, which causes the pituitary to secrete another hormone, adrenocorticotrophic hormone, into the bloodstream. High levels of adrenocorticotrophic hormone are detected within the adrenal glands and stimulate the secretion of cortisol, causing blood levels of cortisol to rise. As the cortisol levels rise, they begin to dam the discharge of corticotrophin-releasing hormone from the hypothalamus and adrenocorticotrophic hormone from the pituitary. As a result, the adrenocorticotrophic hormone levels start to drop, which then results in a drop by cortisol levels. This is called a negative feedback loop. Because most bodily cells have cortisol receptors, it affects many different functions in the body. Cortisol can help control blood sugar levels, regulate metabolism, help reduce inflammation, and assist with memory formulation. It has a controlling effect on salt and water balance and helps control blood pressure. In women, cortisol also supports the developing fetus during pregnancy. All of these functions make cortisol a crucial hormone to protect overall health and well-being. The adrenal glands release cortisol in response to stress or fear as part of the body's fight or flight response. When confronted by some type of threat in your environment, your body goes through a series of nearinstantaneous reactions that prepare you to either stay and affect the matter or escape to safety. A brain structure known as the amygdala alerts the hypothalamus, which then signals a range of responses including the release of hormones such as adrenaline and cortisol [3-5].

References

1. Ramamoorthy S, Cidlowski JA Corticosteroids:Mechanisms of action in health and disease. Rheumatic Disease Clinics. (2016); 42(1):15-31.
2. Neary N, Nieman L. Adrenal insufficiency, et al, Etiologydiagnosis and treatment. Curr Opin Endocrinol DiabetesObes. (2010); 17(3):217-223.
3. Exton JH. Regulation of gluconeogenesis by glucocorticoids. Monogr Endocrinol. (1979);12:535-546.
4. Lee DY, Kim E, Choi MH, et al, Technical and clinical aspects of cortisol as a biochemical marker of chronicstress. BMB Rep. (2015); 48(4):209-216.
5. Kadmiel M, Cidlowski JA. Glucocorticoid receptor signaling in health and disease. Trends Pharmacol Sci.(2013); 34(9):518-530.