Journal of Molecular Oncology Research

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Mini Review - Journal of Molecular Oncology Research (2023) Volume 7, Issue 4

Studies on the effects of post-operative chemotherapy on patients with stomach cancer and sentinel symptoms.

Marielle Dent *

Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA

*Corresponding Author:
Marielle Dent
Department of Medicine
Hospital of the University of Pennsylvania
Philadelphia, USA
E-mail:marielle@dent.edu

Received:28-Jun-2023, Manuscript No. AAMOR-23-103541; Editor assigned:30-Jun-2023, PreQC No. AAMOR-23-103541 (PQ); Reviewed:13-July-2023, QC No. AAMOR-23-103541; Revised:17-July-2023, Manuscript No. AAMOR-23-103541 (R); Published:24-July-2023, DOI:10.35841/ aamor-7.4.189

Citation: Dent M. Studies on the effects of post-operative chemotherapy on patients with stomach cancer and sentinel symptoms. : Mol Cancer Res. 2023;7(4):189

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Abstract

Gastric cancer is a prevalent malignancy worldwide, and post-operative chemotherapy is a common therapeutic approach to improve patient outcomes. However, the efficacy and tolerability of postoperative chemotherapy can vary significantly among patients. This research aims to investigate the concept of "sentinel symptoms" and identify the factors that influence how post-operative chemotherapy affects patients with gastric cancer. The concept of "sentinel symptoms" refers to a set of early signs or indications that may predict the response and tolerability of chemotherapy in patients with gastric cancer. These symptoms can include specific clinical manifestations, laboratory findings, or patient-reported outcomes. Recognizing and monitoring sentinel symptoms can enable healthcare professionals to anticipate treatment response and potentially tailor chemotherapy regimens accordingly

Abstract

Gastric cancer is a prevalent malignancy worldwide, and post-operative chemotherapy is a common therapeutic approach to improve patient outcomes. However, the efficacy and tolerability of post-operative chemotherapy can vary significantly among patients. This research aims to investigate the concept of "sentinel symptoms" and identify the factors that influence how post-operative chemotherapy affects patients with gastric cancer. The concept of "sentinel symptoms" refers to a set of early signs or indications that may predict the response and tolerability of chemotherapy in patients with gastric cancer. These symptoms can include specific clinical manifestations, laboratory findings, or patient-reported outcomes. Recognizing and monitoring sentinel symptoms can enable healthcare professionals to anticipate treatment response and potentially tailor chemotherapy regimens accordingly

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Keywords

Sentinel symptoms, Post-operative chemotherapy, Gastric cancer, Factors, predictive models, Clinical outcomes.

Introduction

Gastric cancer remains a significant global health concern, accounting for a substantial number of cancer-related deaths worldwide. While surgical resection is a cornerstone of curative treatment for localized gastric cancer, the risk of recurrence and metastasis necessitates the use of adjuvant therapies such as post-operative chemotherapy. However, the response to chemotherapy and its associated adverse effects can vary widely among patients. Identifying predictive markers, such as sentinel symptoms, and understanding the factors that influence chemotherapy outcomes in gastric cancer patients are crucial steps toward optimizing treatment strategies and improving patient care [1].

Despite extensive research in the field of gastric cancer treatment, a comprehensive review synthesizing the current knowledge regarding sentinel symptoms and the various factors influencing post-operative chemotherapy outcomes is lacking. Such a review would provide valuable insights into personalized treatment approaches and help optimize patient care. By identifying and understanding these factors, healthcare professionals can tailor treatment plans based on individual patient characteristics, leading to improved clinical outcomes and enhanced quality of life [2].

Bridge this gap by conducting a comprehensive review of the literature, analyzing studies up until September 2021. The review will focus on evaluating the association between sentinel symptoms and post-operative chemotherapy outcomes in patients with gastric cancer. Additionally, the review will explore the influence of demographic, tumor-related, patient-related, and treatment-related factors on treatment response and adverse events [3].

This research will contribute to the current knowledge on sentinel symptoms and the factors that affect post-operative chemotherapy outcomes in gastric cancer patients. The results will help guide clinicians in predicting treatment response and minimizing adverse events through personalized treatment strategies. Furthermore, the identification of predictive markers and risk factors may pave the way for the development of predictive models or risk stratification tools, enabling more accurate treatment decision-making and ultimately improving patient outcomes in the management of gastric cancer [4],[5].

Conclusion

Research on sentinel symptoms and factors influencing the impact of post-operative chemotherapy on patients with gastric cancer sheds light on optimizing treatment approaches and improving patient care. By recognizing sentinel symptoms and considering various factors, clinicians can tailor treatment plans to individual patients, leading to enhanced treatment outcomes and better quality of life for gastric cancer patients undergoing post-operative chemotherapy. Continued research in this field is essential for further refining personalized treatment strategies and advancing the field of gastric cancer management.

References

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  2. Dunn LJ, Robertson AG, Shenfine J, et al. Indocyanine green fluorescence imaging of sentinel nodes in gastric cancer. Ann Surg. 2009;250(4):653.

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  3. Cianci S, Abatini C, Fagotti A, et al. Hyperthermic intraperitoneal chemotherapy (hipec) for peritoneal malignancies using new hybrid co 2 system: Preliminary experience in referral center. Updates Surg. 2019;71:555-60.

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