Journal of Neuroinformatics and Neuroimaging

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Perspective - Journal of Neuroinformatics and Neuroimaging (2023) Volume 8, Issue 2

Role of host-microbial mutualism in the gut-brain axis

Hui Naoki*

Department of Neuroscience, University of Tsukuba, Tsukuba, Japan

*Corresponding Author:
Hui Naoki
Department of Neuroscience
University of Tsukuba, Tsukuba, Japan
E-mail: naoki.hui@nagalabo.jp

Received: 29-Mar-2023, Manuscript No. AANN-23-97103; Editor assigned: 31-Mar-2023, Pre QC No. AANN-23-97103(PQ); Reviewed: 14-Apr-2023, QC No. AANN-23-97103; Revised: 19-Apr-2023, Manuscript No. AANN-23-97103(R); Published: 26-Apr-2023, DOI: 10.35841/aann-8.2.142

Citation: Naoki H. Role of host-microbial mutualism in the gut-brain axis. J NeuroInform Neuroimaging. 2023;8(2):142

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Abstract

  

Introduction

The gut-brain axis is a complex system that involves the communication between the gastrointestinal tract and the central nervous system. Recent studies have revealed that the gut microbiota plays a vital role in regulating this axis, and disturbances in the microbiota can have profound effects on mental health and well-being. In this article, we will explore the role of host-microbial mutualism in the gut-brain axis. Gut-brain axis involves bidirectional communication between the gut and the brain, which occurs through neural, endocrine, and immune pathways. The vagus nerve, which connects the gut and the brain, is a crucial mediator of this communication. Studies have shown that the gut microbiota can modulate the activity of the vagus nerve, leading to changes in brain function and behavior [1].

One of the ways in which the gut microbiota influences the gut-brain axis is through the production of neurotransmitters. Many of the same neurotransmitters that are produced in the brain, such as serotonin, dopamine, and Gamma-Aminobutyric Acid (GABA), are also produced by the gut microbiota. The production of these neurotransmitters by the gut microbiota has been shown to influence brain function and behavior, including mood, cognition, and anxiety. The gut microbiota also plays a crucial role in the development and function of the immune system, which is closely linked to the gut-brain axis. The gut is the site of the largest accumulation of immune cells in the body, and the gut microbiota plays a critical role in the development and function of these cells. Dysregulation of the immune system in the gut has been linked to a range of psychiatric disorders, including anxiety and depression. The gut microbiota has been shown to have a protective effect on the gut-brain axis by regulating immune function. Studies have shown that the gut microbiota can modulate the activity of immune cells in the gut, leading to a reduction in inflammation and an improvement in gut barrier function. This, in turn, can lead to a reduction in the production of pro-inflammatory cytokines, which have been linked to the development of psychiatric disorders [2].

The role of the gut microbiota in the gut-brain axis has also been linked to the development of neurodegenerative diseases. Recent studies have shown that alterations in the gut microbiota can lead to the development of Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The gut microbiota has also been shown to play a role in the development of Autism Spectrum Disorder (ASD) and Attention-Deficit Hyperactivity Disorder (ADHD). One of the ways in which the gut microbiota influences the development of neurodegenerative diseases is through the production of amyloid beta, a protein that is involved in the pathogenesis of Alzheimer's disease. The gut microbiota can produce amyloid beta and transport it to the brain through the bloodstream or the vagus nerve, leading to the formation of amyloid plaques in the brain. This, in turn, can lead to neuronal damage and cognitive decline [3].

Similarly, the gut microbiota has been shown to play a role in the development of Parkinson's disease. Studies have shown that individuals with Parkinson's disease have a different gut microbiota composition than healthy individuals. Dysbiosis in the gut microbiota can lead to the accumulation of alphasynuclein, a protein that is involved in the pathogenesis of Parkinson's disease, in the enteric nervous system. This, in turn, can lead to the spread of alpha-synuclein to the brain through the vagus nerve, leading to the development of Parkinson's disease.

The gut microbiota also plays a role in the development of ASD and ADHD. Studies have shown that individuals with ASD and ADHD have a different gut microbiota composition than healthy individuals. Dysbiosis in the gut microbiota can lead to the production of metabolites, such as propionic acid, that have neurotoxic effects and can contribute to the development of these disorders [4].

Host-microbial mutualism is essential for maintaining a healthy gut microbiota and a functional gut-brain axis. Disruptions in this mutualism, such as the use of antibiotics, can have significant effects on gut microbiota composition and function. Antibiotics can lead to dysbiosis in the gut microbiota, leading to changes in brain function and behavior. The use of antibiotics has been linked to the development of psychiatric disorders, such as depression and anxiety, as well as neurodegenerative diseases [5].

Conclusion

The gut microbiota plays a vital role in regulating the gut-brain axis, and disruptions in this axis can lead to the development of psychiatric and neurodegenerative disorders. Hostmicrobial mutualism is essential for maintaining a healthy gut microbiota and a functional gut-brain axis. Understanding the role of the gut microbiota in the gut-brain axis can lead to the development of new therapeutic interventions for psychiatric and neurodegenerative disorders.

References

  1. Heijtz RD, Wang S, Anuar F, et al. Normal gut microbiota modulates brain development and behavior. Proc Natl Acad Sci. 2011;108(7):3047-52.

    2. Indexed at, Google Scholar, Cross Ref

  2. El Aidy S, Dinan TG, Cryan JF. Immune modulation of the brain-gut-microbe axis. Front Microbiol. 2014;5:146.

    3. Indexed at, Google Scholar, Cross Ref

  3. Tomkovich S, Jobin C. Microbiota and host immune responses: A love–hate relationship. Immunology. 2016;147(1):1-0.

    4. Indexed at, Google Scholar, Cross Ref

  4. Patterson E, Cryan JF, Fitzgerald GF, et al. Gut microbiota, the pharmabiotics they produce and host health. Proc Nutr Soc. 2014;73(4):477-89.

    5. Indexed at, Google Scholar, Cross Ref

  5. Jiang HY, Zhang X, Yu ZH, et al. Altered gut microbiota profile in patients with generalized anxiety disorder. J Psychiatr Res. 2018;104:130-6.

    6. Indexed at, Google Scholar, Cross Ref

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