Journal of Advanced Surgical Research

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-1518-081136

Short Communication - Journal of Advanced Surgical Research (2023) Volume 7, Issue 3

Recent innovations in tissue engineering for regenerative medicine in surgery

Anna Tobita*

Medical Technology Innovation Center, Juntendo University, Tokyo, Japan

*Corresponding Author:
Anna Tobita
Medical Technology Innovation Center
Juntendo University, Tokyo, Japan
E-mail: atobita@juntendo.ac.jp

Received: 02-May -2023, Manuscript No. AAASR-23-102982; Editor assigned: 03-May-2023, PreQC No. AAASR-23-102982 (PQ); Reviewed: 17 -May-2023, QC No. AAASR-23-102982; Revised: 23-May-2023, Manuscript No. AAASR-23-102982(R); Published: 30-May-2023, DOI:10.35841/2591-7765-7.3.147

Citation: Tobita A. Recent innovations in tissue engineering for regenerative medicine in surgery. J Adv Surge Res. 2023;7(3):147

Visit for more related articles at Journal of Advanced Surgical Research

Introduction

Tissue engineering has emerged as a promising approach for regenerative medicine, aiming to restore or replace damaged tissues and organs through the application of biological, engineering, and medical principles. In the field of surgery, tissue engineering offers innovative solutions to address the limitations of traditional surgical interventions. This article aims to provide an overview of recent innovations in tissue engineering and their potential applications in surgical practice [1].

Scaffold-based approaches play a crucial role in tissue engineering by providing a three-dimensional (3D) structure that mimics the extracellular matrix (ECM) of native tissues. Recent advancements in scaffold design have focused on enhancing their biocompatibility, mechanical properties, and bioactive cues. Techniques such as electrospinning, 3D printing, and decellularized scaffolds have shown promise in generating scaffolds with desired properties for tissue regeneration [2].

The selection of suitable biomaterials is vital for successful tissue engineering applications. Recent developments in biomaterials have led to the creation of novel materials with improved biocompatibility, bioactivity, and degradation characteristics. Examples include biodegradable polymers, hydrogels, and composite materials. These biomaterials can provide mechanical support, release growth factors, and promote cell adhesion and proliferation, thus facilitating tissue regeneration [3].

Cell-based therapies are an integral component of tissue engineering approaches. Recent advances have expanded the range of cell sources available for tissue engineering, including stem cells, induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs). These cells can differentiate into various cell lineages and possess regenerative properties, making them ideal candidates for tissue repair and regeneration in surgical applications.

Bioprinting has emerged as a cutting-edge technology in tissue engineering, enabling precise spatial arrangement of cells, biomaterials, and growth factors to create functional tissues and organs. Recent innovations in bioprinting techniques, such as extrusion-based and inkjet-based bioprinting, have shown tremendous potential in generating complex tissue structures with high precision and scalability. Bioprinting holds great promise for customizing tissue constructs according to patientspecific needs, revolutionizing surgical interventions [4].

While tissue engineering has made significant progress, several challenges need to be addressed for successful clinical translation. These include vascularization of engineered tissues, immune responses, scalability, and regulatory hurdles. Ongoing research efforts aim to overcome these challenges and optimize tissue engineering approaches for widespread clinical use. Future prospects include the integration of bioactive molecules, nanotechnology, and artificial intelligence to enhance tissue regeneration and surgical outcomes [5].

References

  1. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32(8):773-85.

    2. Indexed at, Google Scholar, Cross Ref

  2. Blaeser A, Duarte Campos DF, Puster U, et al. Controlling shear stress in 3D bioprinting is a key factor to balance printing resolution and stem cell integrity. Adv Healthc Mater. 2016;5(3):326-33.

    3. Indexed at, Google Scholar, Cross Ref

  3. Zhang YS, Khademhosseini A. Advances in engineering hydrogels. Sci. 2017;356(6337):3627.

    4. Indexed at, Google Scholar, Cross Ref

  4. Hutmacher DW. Scaffold design and fabrication technologies for engineering tissues-state of the art and future perspectives. J Biomater Sci Polym Ed. 2001;12(1):107-24.

    5. Indexed at, Google Scholar, Cross Ref

  5. Ji S, Guvendiren M. Recent advances in bioink design for 3D bioprinting of tissues and organs. Front Bioeng Biotechnol. 2017;5:23.

    6. Indexed at, Google Scholar, Cross Ref

Get the App