Journal of Cell Science and Mutations

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
Reach Us +44-1518-081136

Mini Review - Journal of Cell Science and Mutations (2023) Volume 7, Issue 5

Precision Medicine in the Genomic Era: Targeting Mutations for Personalized Cell Therapies

Lisa Joerg *

Department of Cell Biology, The University of Melbourne, Australia

*Corresponding Author:
Lisa Joerg
Department of Cell Biology, The University of Melbourne, Australia
E-mail: lisa@unimelb.edu.aucn

Received: 05-Sept-2023, Manuscript No. AAACSM -23-112034; Editor assigned: 06- Sept -2023, PreQC No. AAACSM -23-112034 (PQ); Reviewed:19- Sept -2023, QC No. AAACSM -23-112034; Revised:21-Sept -2023, Manuscript No. AAACSM -23-112034 (R); Published:28- Sept -2023, DOI:10.35841/aaacsm-7.5.162

Citation: Joerg L. Precision Medicine in the Genomic Era: Targeting Mutations for Personalized Cell Therapies. J Cell Sci Mut. 2023;7(5):162

Visit for more related articles at Journal of Cell Science and Mutations

Introduction

The landscape of healthcare has been transformed by the advent of precision medicine, an approach that tailors medical decisions, interventions, and treatments to the individual characteristics of each patient. In the genomic era, where our understanding of genetics and cellular processes has reached unprecedented levels, precision medicine has taken center stage. By harnessing the power of genomics and molecular biology, researchers and clinicians are now exploring the realm of personalized cell therapies, aiming to address diseases at their root by targeting specific mutations unique to each patient [1].

Genomics, the study of an organism's entire DNA sequence, has unveiled a wealth of information about genetic variations that influence disease susceptibility, progression, and response to treatment. The Human Genome Project marked a pivotal milestone, paving the way for comprehensive analyses of individual genomes. This knowledge has enabled the identification of genetic mutations associated with various diseases, from monogenic disorders like cystic fibrosis to complex conditions like cancer and cardiovascular diseases [2].

Many diseases arise from genetic mutations that disrupt normal cellular processes. In the context of precision medicine, understanding these mutations on a cellular and molecular level is crucial. Advanced techniques, such as CRISPR-Cas9 gene editing and single-cell sequencing, allow researchers to dissect the intricate mechanisms underlying disease-associated mutations. This knowledge provides insights into how specific mutations lead to cellular dysfunction and can guide the development of targeted therapies [3].

Traditional treatment approaches often follow a one-size-fits-all model, which might not be effective for every patient due to genetic variability. Personalized cell therapies, on the other hand, involve modifying or replacing a patient's own cells to correct or mitigate the effects of genetic mutations. This can take the form of gene therapies, where a functional copy of a defective gene is introduced into the patient's cells, or cell-based therapies, where engineered cells are used to replace damaged or malfunctioning ones [4].

The development of precise and efficient gene editing techniques, particularly CRISPR-Cas9, has revolutionized the field of personalized medicine. CRISPR allows researchers to modify DNA sequences with unprecedented accuracy, opening doors for correcting genetic mutations responsible for diseases. Clinical trials are underway to explore the potential of CRISPR-based therapies for conditions such as sickle cell anemia and beta-thalassemia, providing promising glimpses into a future where genetic diseases could be treated at their source [5].

Conclusion

Precision medicine has ushered in a new era of healthcare where treatments are tailored to the unique genetic makeup of each individual. With the genomic revolution at its core, personalized cell therapies hold immense promise for addressing a wide spectrum of diseases. By targeting mutations at the cellular level, researchers are inching closer to realizing the vision of truly individualized medicine. As the field advances, the collaboration between scientific innovation, medical expertise, and ethical considerations will shape the future of healthcare in an unprecedented way.

References

  1. Yuan M, Huang LL. The emerging treatment landscape of targeted therapy in non-small-cell lung cancer. Sig trans tar ther. 2019;4(1):61.

    2. Indexed at, Google Scholar, Cross Ref

  2. Barquin M, Calvo V, Franco F, Sánchez E. Next-generation sequencing for tumor mutation quantification using liquid biopsies. Cli Chem Lab Med (CCLM). 2020;58(2):306-13.

    3. Indexed at, Google Scholar, Cross Ref

  3. Araf S, Korfi K, Rahim T. Advances in the molecular diagnosis of diffuse large B-cell lymphoma in the era of precision medicine. Exp Rev Mol Diag. 2016;16(10):1093-102.

    4. Indexed at, Google Scholar, Cross Ref

  4. Omar A, Zhou M, Berman A,. Genomic-based diagnosis of arrhythmia disease in a personalized medicine era. Exp rev prec med drug develop. 2016;1(6):497-504.

    5. Indexed at, Google Scholar, Cross Ref

  5. Kaprio J, Foreman M, Baurley JW,. Leveraging genomic data in smoking cessation trials in the era of precision medicine: why and how. Nicotine and Tobacco Research. 2018;20(4):414-24.

    6. Indexed at, Google Scholar, Cross Ref

Get the App