Commentary - Journal of Pharmaceutical Chemistry & Chemical Science (2023) Volume 7, Issue 2

Investigating drug-induced toxicity: Chemical mechanisms and mitigation strategies

Kevin Liu ^*

Department of Biomedical Sciences, University of Edinburgh, Edinburgh, United Kingdom

*Corresponding Author:

Kevin Liu
Department of Biomedical Sciences,
University of Edinburgh,
Edinburgh, United Kingdom
E-mail: kevin@li.uk

Received: 27-Mar-2023, Manuscript No. AAPCCS-23-97201; Editor assigned: 30-Mar-2023, PreQC No. AAPCCS-23-97201(PQ); Reviewed: 13-Apr-2023, QC No. AAPCCS-23-97201; Revised: 17-Apr-2023, Manuscript No. AAPCCS-23-97201; Published: 24-Apr-2023, DOI:10.35841/aapccs-7.2.141

Citation: Liu K. Investigating drug-induced toxicity: Chemical mechanisms and mitigation strategies. J Pharm Chem Chem Sci 2023;7(2):141

Abstract

Drug-induced toxicity, also known as drug-induced adverse reactions, is a significant concern in the development and use of pharmaceuticals. The occurrence of drug-induced toxicity can result in severe side effects, which can range from mild skin rashes to organ failure and death. As such, understanding the chemical mechanisms of drug-induced toxicity and developing effective mitigation strategies is essential.

Keywords

Drugs, Toxicity, Mechanisms, Drug-induced adverse reactions, Enzymes.

Introduction

Drug toxicity is a leading cause of attrition of candidate drugs during drug development as well as of withdrawal of drugs post-licensing due to adverse drug reactions in man. These adverse drug reactions cause a broad range of clinically severe conditions including both highly reproducible and dose dependent toxicities as well as relatively infrequent and idiosyncratic adverse events [1].

Drug-induced toxicity can occur via a variety of chemical mechanisms. One of the most common mechanisms is the production of reactive metabolites. When a drug is metabolized in the liver, it may form reactive metabolites that can bind to proteins and nucleic acids, leading to cell damage and death. This can result in liver damage, as well as damage to other organs and tissues [2].

Another common mechanism of drug-induced toxicity is the inhibition of enzymes involved in drug metabolism. When a drug inhibits these enzymes, it can lead to an accumulation of the drug or its metabolites, which can result in toxicity. For example, the commonly used painkiller acetaminophen is metabolized by the liver enzyme CYP2E1. However, in high doses, acetaminophen can inhibit this enzyme, leading to the accumulation of a toxic metabolite that can cause liver damage002E

Other mechanisms of drug-induced toxicity include the disruption of cellular signaling pathways, interference with ion channels, and the induction of oxidative stress. In all cases, drug-induced toxicity can result in a range of adverse effects, including inflammation, cell death, and tissue damage [3].

To mitigate drug-induced toxicity, pharmaceutical companies must take several steps during the drug development process. First, drugs must be thoroughly tested in preclinical studies to identify potential toxicity issues. This includes testing in animal models and in vitro assays to assess the drug's toxicity profile. Once a drug is approved for clinical use, post-marketing surveillance is critical to identifying any unexpected toxicity issues. This includes monitoring adverse events reported by healthcare providers and patients, as well as conducting further clinical studies to assess the drug's safety profile [4].

Additionally, several strategies can be employed to mitigate drug-induced toxicity. For example, drugs can be designed to minimize the formation of reactive metabolites, or to target specific enzymes involved in drug metabolism to reduce the risk of enzyme inhibition. Additionally, drugs can be formulated to improve their pharmacokinetic properties, such as their solubility and stability, which can reduce the risk of toxicity [5].

Conclusion

Drug-induced toxicity is a significant concern in the development and use of pharmaceuticals. Understanding the chemical mechanisms of drug-induced toxicity and developing effective mitigation strategies is essential to ensure the safety and efficacy of new drugs. By employing rigorous preclinical testing and post-marketing surveillance, as well as developing drugs with improved pharmacokinetic properties and reduced toxicity risk, pharmaceutical companies can minimize the risk of drug-induced toxicity and improve patient outcomes

.

References

1. Hynes J, Marroquin LD, Ogurtsov VI, et al. Investigation of drug-induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes. Toxicol Sci. 2006;92(1):186-200.

   Indexed at, Google Scholar, Cross Ref

2. Penman SL, Carter AS, Chadwick AE. Investigating the importance of individual mitochondrial genotype in susceptibility to drug-induced toxicity. Biochem Soc Trans. 2020;48(3):787-97.

   Indexed at, Google Scholar, Cross Ref

3. Pereira CV, Moreira AC, Pereira SP, et al. Investigating drug-induced mitochondrial toxicity: A biosensor to increase drug safety? Curr Drug Saf. 2009;4(1):34-54.

   Indexed at, Google Scholar, Cross Ref

4. Yen NT, Park SM, Thu VT, et al. Genome-wide gene expression analysis reveals molecular insights into the drug-induced toxicity of nephrotoxic agents. Life Sci. 2022;306:120801.

   Indexed at, Google Scholar, Cross Ref

5. Liebler DC, Guengerich FP. Elucidating mechanisms of drug-induced toxicity. Nat Rev Drug Discov. 2005;4(5):410-20.

   Indexed at, Google Scholar, Cross Ref