Journal of Neurology and Neurorehabilitation Research

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Perspective - Journal of Neurology and Neurorehabilitation Research (2024) Volume 9, Issue 5

Genetic Influences on Neurological Development: Insights from Pediatric Neurology

Selina Anwaa *

Department of Paediatrics, University of Montreal, Canada

*Corresponding Author:
Selina Anwaa
Department of Paediatrics, University of Montreal, Canada
E-mail: anwaa@um.cn.in

Received: 22-Aug-2024, Manuscript No. JNNR-24-150908; Editor assigned: 24-Aug-2024, PreQC No. JNNR-24-150908(PQ); Reviewed: 07-Sep-2024, QC No. JNNR-24-150908; Revised: 12-Sep-2024, Manuscript No. JNNR-24-150908(R); Published: 19-Sep-2024, DOI: 10.35841/aajnnr-9.5.228

Citation: : Anwaa S. Genetic Influences on Neurological Development: Insights from Pediatric Neurology. J Neurol Neurorehab Res.2024;9(5):228

Introduction

Genetic influences play a crucial role in neurological development, with ongoing research in pediatric neurology providing valuable insights into how genes shape brain function from early life [1]. The development of the nervous system is a complex process involving gene expression, signaling pathways, and environmental interactions, all of which can influence a child's cognitive and motor skills, behavior, and overall neurological health [2]. Genetic mutations, variations, or disruptions can lead to a wide range of neurodevelopmental disorders, such as autism spectrum disorder (ASD), epilepsy, intellectual disabilities, and more [3].

Many neurological disorders observed in children have a genetic basis, whether they are inherited or result from de novo mutations. Advances in genomic technologies, such as next-generation sequencing, have allowed for the identification of specific genes associated with these conditions [4]. For instance, mutations in the MECP2 gene are linked to Rett syndrome, a severe neurodevelopmental disorde r primarily affecting females, while variations in the SCN1A gene are associated with Dravet syndrome, a severe form of childhood epilepsy. Identifying these genetic links allows for early diagnosis and, in some cases, targeted therapeutic approaches that can improve outcomes [5].

Beyond single-gene mutations, polygenic influences are also significant in neurological development. Complex traits, such as intelligence, behavior, and susceptibility to neurological disorders, often involve the interaction of multiple genes [6]. For example, autism spectrum disorder is understood to result from the combined effect of numerous genetic variants, each contributing a small degree of risk [7]. The genetic architecture of these conditions highlights the importance of understanding how genes interact with each other and with environmental factors, such as prenatal exposure to toxins or nutritional deficiencies [8].

Pediatric neurology also explores the role of epigenetics in neurological development. Epigenetic changes, which do not alter the DNA sequence but affect gene expression, can be influenced by external factors like stress, diet, and early childhood experiences. These changes can have long-lasting effects on brain development, potentially contributing to conditions like attention-deficit/hyperactivity disorder (ADHD) or learning disabilities [9].

Understanding genetic influences on neurological development has important implications for diagnosis, treatment, and early intervention. Genetic screening and counseling can help families identify risks early on and provide personalized care strategies. Furthermore, ongoing research into gene therapy and other precision medicine approaches offers hope for more effective treatments for genetic neurological conditions. Insights from pediatric neurology continue to advance the field, helping clinicians better understand, diagnose, and manage neurological disorders in children [10].

Conclusion

Genetic influences are fundamental to neurological development, with pediatric neurology offering critical insights into how specific genes and their interactions shape brain function and contribute to neurodevelopmental disorders. Advances in genetic research have enhanced our understanding of the causes of conditions like autism, epilepsy, and intellectual disabilities, enabling earlier diagnosis and more personalized treatment options.

References

  1. Scher MS. Gene-environment interactions during the first thousand days influence childhood neurological diagnosis. Semin Pediatr Neurol. 2022;42:100970.

    2. Indexed at, Google Scholar, Cross Ref

  2. Tardieu M. Paediatric neurology: brain development at an interface between genetics, the environment, and the immune system. Lancet Neurol. 2010;9(1):13-4.

    3. Indexed at, Google Scholar, Cross Ref

  3. Scher MS, Agarwal S, Venkatesen C. Clinical decisions in fetal-neonatal neurology II: Gene-environment expression over the first 1000 days presenting as “four great neurological syndromes”. Semin Fetal Neonatal Med. 2024: 101522.

    4. Indexed at, Google Scholar, Cross Ref

  4. Sarnat HB, Flores-Sarnat L. Neuroembryonic and fetal brain development: Relevance to fetal/neonatal neurological training. Semin Fetal Neonatal Med. 2024: 101520.

    5. Indexed at, Google Scholar, Cross Ref

  5. Capone GT. Down syndrome: Genetic insights and thoughts on early intervention. Infants Young Child. 2004;17(1):45-58.

    6. Google Scholar

  6. Ismail FY, Fatemi A, Johnston MV. Cerebral plasticity: Windows of opportunity in the developing brain. Eur J Paediatr Neurol. 2017;21(1):23-48.

    7. Indexed at, Google Scholar, Cross Ref

  7. Fasaludeen A, McTague A, Jose M, et al. Genetic variant interpretation for the neurologist-A pragmatic approach in the next-generation sequencing era in childhood epilepsy. Epilepsy Res. 2024:107341.

    8. Indexed at, Google Scholar, Cross Ref

  8. Olney JW. New insights and new issues in developmental neurotoxicology. Neurotoxicology. 2002;23(6):659-68.

    9. Indexed at, Google Scholar, Cross Ref

  9. Neubauer BA, Lemke JR. From genetics to genomics: a short introduction for pediatric neurologists. Neuropediatrics. 2016;47(01):005-11.

    10. Indexed at, Google Scholar, Cross Ref

  10. Sarnat HB, Flores-Sarnat L. Pediatric Neurology Part I: Chapter 12. Neuroembryology and brain malformations: an overview.

    11. Indexed at, Google Scholar, Cross Ref

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