Allied Journal of Medical Research

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Mini Review - Allied Journal of Medical Research (2023) Volume 7, Issue 6

Gastrointestinal Pathology and the Microbiome: Deciphering the Gut's Hidden Influence

Sachiko Chadborn *

Department of Health Sciences, Cardiff University, Cardiff, UK

*Corresponding Author:
Sachiko Chadborn
Department of Health Sciences, Cardiff University, Cardiff, UK
Northwest A&F University
UK
E-mail: Chadborn@nbu.edu

Received: 28-Oct-2023, Manuscript No. AAAJMR -23-19519; Editor assigned: 31-Oct-2023, PreQC No. AAAJMR -23-19519 (PQ); Reviewed: 14-Nov-2023, QC No. AAAJMR -23-19519; Revised:20-Nov-2023, Manuscript No. AAAJMR-23-19519 (R); Published: 27-Nov-2023, DOI:10.35841/ aaajmr-7.6.202

Citation Keng D. Gastrointestinal pathology and the microbiome: Deciphering the gut's hidden influence. Allied J Med Res. 2023;7(6):203

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Introduction

Introduction

In the intricate world of gastrointestinal pathology, a relatively recent revelation has reshaped our understanding of digestive health-the gut microbiome. This complex and dynamic ecosystem of microorganisms residing in the gastrointestinal tract has emerged as a central player in health and disease. Its intricate interactions with the human body have broad implications for gastrointestinal pathology, offering new insights into the development, progression, and management of digestive disorders. [1]

In this article, we delve into the profound impact of the gut microbiome on gastrointestinal pathology, highlighting the symbiotic relationship between the trillions of microorganisms that call our intestines home and the intricate mechanisms underlying various digestive conditions. [2].

The gut microbiome comprises a vast array of bacteria, viruses, fungi, and other microorganisms, collectively weighing in at a staggering three to four pounds in the average adult. This bustling community not only aids in the digestion and absorption of nutrients but also contributes to immune system function and influences metabolic processes. Furthermore, it has been implicated in neurological health, with growing evidence of its role in conditions like Parkinson's disease and depression. [3].

Gastrointestinal disorders and dysbiosis

One of the most compelling aspects of the gut microbiome's influence is its role in gastrointestinal pathology. Dysbiosis, an imbalance in the gut microbial community, has been linked to an array of digestive disorders. Conditions such as Irritable Bowel Syndrome (IBS), Inflammatory Bowel Disease (IBD), and colorectal cancer have all been associated with disruptions in the gut microbiome. The nuanced interplay between the microbiome and the gut lining can exacerbate inflammation, contributing to the pathogenesis of these disorders. [4].

Inflammatory bowel disease and the microbiome connection

In the realm of gastrointestinal pathology, the relationship between the gut microbiome and inflammatory bowel disease is a particularly salient example [5].

Research has unveiled intricate connections between specific bacterial strains and the severity of IBD, which encompasses Crohn's disease and ulcerative colitis. A deeper understanding of this interaction may hold the key to developing novel therapeutic approaches, including targeted interventions that focus on restoring a balanced microbial environment [6].

The influence of the gut microbiome has prompted a wave of research into microbiome-targeted therapies. Fecal Microbiota Transplantation (FMT), for instance, has shown promise in the treatment of Clostridium difficile infections and some cases of IBD, emphasizing the potential for harnessing the therapeutic power of the microbiome itself [7].

Additionally, probiotics and prebiotics are being explored as tools to modulate the gut microbiome, potentially mitigating the risk of gastrointestinal pathology [8].

As our understanding of the gut microbiome deepens, so does the potential for transforming our approach to gastrointestinal pathology. Research continues to explore the intricate relationships between the gut microbiome and an array of digestive disorders, with the hope of identifying novel biomarkers, diagnostic tools, and therapeutic strategies [9].

By unraveling the mysteries of the gut microbiome, the field of gastrointestinal pathology is poised to provide more personalized and effective treatments, offering hope to those grappling with digestive diseases [10].

References

  1. Zhang P. Influence of foods and nutrition on the gut microbiome and implications for intestinal health. Int. J. Mol. Sci. 2022;23(17):9588.

    2. Indexed at, Google Scholar, Cross Ref

  2. Khan I, Ullah N, Zha L, et al. Alteration of gut microbiota in inflammatory bowel disease (IBD): Cause or consequence? IBD treatment targeting the gut microbiome. Pathogens. 2019;8(3):126.

    3. Indexed at, Google Scholar, Cross Ref

  3. Virili C, Fallahi P, Antonelli A, et al. Gut microbiota and Hashimoto’s thyroiditis. Reviews in Endocrine and Metabolic Disorders. 2018;19:293-300.

    4. Indexed at, Google Scholar, Cross Ref

  4. Martin CR, Osadchiy V, Kalani A, Mayer EA. The brain-gut-microbiome axis. Cellular and molecular gastroenterology and hepatology. 2018;6(2):133-48.

    5. Indexed at, Google Scholar, Cross Ref

  5. Kandpal M, Indari O, Baral B, et al. Dysbiosis of Gut Microbiota from the Perspective of the Gut–Brain Axis: Role in the Provocation of Neurological Disorders. Metabolites. 2022;12(11):1064.

    6. Indexed at, Google Scholar, Cross Ref

  6. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. science. 2012;336(6086):1268-73.

    7. Google Scholar

  7. Rosen CE, Palm NW. Functional Classification of the Gut Microbiota: The Key to Cracking the Microbiota Composition Code: Functional classifications of the gut microbiota reveal previously hidden contributions of indigenous gut bacteria to human health and disease. BioEssays. 2017;39(12):1700032.

    8. Indexed at, Google Scholar, Cross Ref

  8. Takiishi T, Fenero CI, Câmara NO. Intestinal barrier and gut microbiota: Shaping our immune responses throughout life. Tissue barriers. 2017;5(4):e1373208.

    9. Indexed at, Google Scholar, Cross Ref

  9. Lerner A, Neidhöfer S, Matthias T. The gut microbiome feelings of the brain: A perspective for non-microbiologists. Microorganisms. 2017;5(4):66.

    10. Indexed at, Google Scholar, Cross Ref

  10. Carbone C, Piro G, Di Noia V, et al. Lung and gut microbiota as potential hidden driver of immunotherapy efficacy in lung cancer. Mediators of inflammation. 2019.

    11. Indexed at, Google Scholar, Cross Ref

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