Rapid Communication - Journal of Clinical Oncology and Cancer Research (2023) Volume 6, Issue 3

Emerging Trends in Cancer Treatment: From CAR-T Cell Therapy to Oncolytic Viruses

Department of pathology Sri Venkateshwaraa College of Paramedical Sciences, Pondicherry, India

*Corresponding Author:

Vayaravel Nanda
Department of pathology
Sri Venkateshwaraa College of Paramedical Sciences
Pondicherry, India
E-mail: cam23@gmail.com

Received: 02-Jun-2023, Manuscript No.AACOCR-23-104449; Editor assigned: 04-Jun-2023, PreQC No.AACOCR-23-104449 (PQ); Reviewed: 18-Jun-2023, QC No.AACOCR-23-104449; Revised: 21-Jun-2023, Manuscript No.AACOCR-23-104449 (R); Published: 25-Jun-2023, DOI:10.35841/aacocr-6.3.147

Citation: Nanda V. Emerging trends in cancer treatment: From car-t cell therapy to oncolytic viruses. J Clin Oncol Cancer Res. 2023;6(3):147

Introduction

Cancer continues to be one of the most pressing global health challenges, affecting millions of lives worldwide. The field of oncology is witnessing remarkable advancements, with scientists, researchers, and medical professionals constantly striving to discover innovative approaches to cancer treatment. In recent years, several emerging trends have shown great promise in transforming the landscape of cancer therapy. This article explores some of these breakthrough trends that are revolutionizing the way we diagnose, treat, and manage cancer.

Immunotherapy: Unleashing the Power of the Immune System Immunotherapy has emerged as a game-changer in cancer treatment. This approach harnesses the body's own immune system to recognize and eliminate cancer cells. Immune checkpoint inhibitors, such as pembrolizumab and nivolumab, have shown impressive results in treating various types of cancer, including melanoma, lung cancer, and bladder cancer. Chimeric Antigen Receptor (CAR) T-cell therapy, another form of immunotherapy, involves modifying a patient's T cells to recognize and attack cancer cells. CAR-T therapy has demonstrated remarkable success in treating certain blood cancers, such as leukemia and lymphoma [1].

Precision medicine: Tailoring Treatment to Individual Patients Precision medicine, also known as personalized medicine, is an approach that considers the unique genetic, molecular, and environmental factors of each patient to design personalized treatment plans. Genomic profiling allows oncologists to identify specific genetic mutations and alterations in tumors, enabling targeted therapies that attack cancer cells with precision. The advent of next-generation sequencing technologies has facilitated rapid and costeffective sequencing of tumor genomes, providing valuable insights into tumor biology and guiding treatment decisions [2].

Liquid biopsies: Non-Invasive Detection and Monitoring Traditionally, biopsies involve the invasive collection of tissue samples for diagnosis and monitoring of cancer. However, liquid biopsies are revolutionizing this process by analyzing Circulating Tumor Cells (CTCs), cell-free DNA (cfDNA), and other biomarkers present in blood samples. Liquid biopsies offer a non-invasive and repeatable method for early cancer detection, monitoring treatment response, and detecting genetic alterations or resistance mechanisms. This emerging technology holds great potential for improving cancer diagnosis and treatment monitoring while minimizing patient discomfort [3].

Targeted therapies: Targeted therapies focus on specific molecules or pathways that play a critical role in tumor growth and progression. These therapies interfere with the signaling pathways that promote cancer cell survival, proliferation, and angiogenesis. Small molecule inhibitors, such as tyrosine kinase inhibitors, have shown remarkable success in treating various cancers, including breast, lung, and colorectal cancers. Monoclonal antibodies, such as trastuzumab and rituximab, target specific cell surface proteins and have transformed the treatment landscape for HER2-positive breast cancer and non- Hodgkin lymphoma, respectively.

Nanotechnology: Delivering Drugs with Precision Nanotechnology involves manipulating materials at the nanoscale to create novel structures and devices with unique properties. In cancer treatment, nanotechnology plays a crucial role in drug delivery systems. Nanoparticles can be engineered to selectively target cancer cells, enhancing drug efficacy and reducing toxicity to healthy tissues. Additionally, nanoscale sensors and imaging agents enable early cancer detection and real-time monitoring of treatment response. Nanotechnology holds immense potential to revolutionize drug delivery, imaging, and diagnostics in cancer treatment [4].

Artificial intelligence and machine learning: Enhancing Cancer Care Artificial Intelligence (AI) and Machine Learning (ML) algorithms are increasingly being utilized in cancer research and clinical practice. AI can analyze vast amounts of patient data, including medical records, imaging studies, and genetic information, to identify [5].

emerging trends in cancer treatment, such as CAR-T cell therapy and oncolytic viruses, are revolutionizing the field of oncology and offering new possibilities for patients facing difficult-to-treat cancers. These innovative approaches are expanding our understanding of cancer biology and providing novel treatment options with the potential for improved outcomes.

Conclusion

CAR-T cell therapy has emerged as a groundbreaking immunotherapy that involves modifying a patient's own immune cells to specifically target cancer cells. By engineering T cells to express chimeric antigen receptors (CARs) that recognize tumor antigens, CAR-T cell therapy has demonstrated remarkable success in certain hematological malignancies, such as leukemia and lymphoma. It has led to durable remissions and even potential cures for some patients who had exhausted all other treatment options.

References

1. Sekar P, Ravitchandirane R, Khanam S, et al. Novel molecules as the emerging trends in cancer treatment: an update. Med Oncol. 2023;39(2):20.

Indexed at, Google Scholar, Cross Ref

2. Rudolph J, Settleman J, Malek S. Emerging trends in cancer drug discovery—from drugging the “Undruggable” to overcoming resistance. Cancer Discov. 2021;11(4):815-21.

Indexed at, Google Scholar, Cross Ref

3. Kumar RR, Kumar A, Chuang CH, et al. Recent advances and emerging trends in cancer biomarker detection technologies. Ind Amp Eng Chem Res. 2023;62(14):5691-713.

Indexed at, Google Scholar, Cross Ref

4. Guerra AR, Duarte MF, Duarte IF. Targeting tumor metabolism with plant-derived natural products: emerging trends in cancer therapy. J Agric Food Chem. 2018;66(41):10663-85.

Indexed at, Google Scholar, Cross Ref

5. Badwaik R. Precision Medicine: Emerging Trends in Cancer Therapy. J Clin Diagnostic Res. 2019;13(10).

Indexed at, Google Scholar, Cross Ref