Journal of Cancer Immunology & Therapy

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Rapid Communication - Journal of Cancer Immunology & Therapy (2023) Volume 6, Issue 3

Effects of tumor-infiltrating lymphocytes on the immune system in cancer.

Ellie Maas*

Department of Obstetrics and Gynecology, University Medical Center Groningen, The Netherlands

*Corresponding Author:
Ellie Maas
Department of Obstetrics and Gynecology
University Medical Center Groningen
Groningen, The Netherlands
E-mail:ellie_ma64@hotmail.com

Received:22-May-2023,Manuscript No. AAJCIT-23-102153; Editor assigned: 25-May-2023, PreQC No. AAJCIT-23-102153(PQ); Reviewed:08-Jun-2023, QC No. AAJCIT-23-102153; Revised:12-Jun-2023, Manuscript No. AAJCIT-23-102153(R); Published:20-Jun-2023, DOI: 10.35841/aajcit- 6.3.152

Citation: Maas E. Effects of tumor-infiltrating lymphocytes on the immune system in cancer. J Cancer Immunol Ther. 2023;6(3):152

Visit for more related articles at Journal of Cancer Immunology & Therapy

Introduction

Tumor-infiltrating lymphocytes (TILs) play a critical role in the immune response against cancer. Their presence and activity within the tumor microenvironment have significant implications for patient prognosis and response to immunotherapies. This article explores the effects of TILs on the immune system in the context of cancer. TILs are a diverse subset of immune cells, primarily T cells that infiltrate the tumor site. They can exhibit an activated or exhausted phenotype depending on the balance between anti-tumor effector functions and immune suppressive signals within the tumor microenvironment. High levels of TIL infiltration have been associated with improved prognosis and better response to immunotherapies in various cancers. However, tumors can employ immune escape mechanisms to evade immune destruction, leading to disease progression[1].

Strategies to manipulate TILs and modulate the tumor microenvironment are being explored to enhance their anti-tumor activity. TILs and the immune system is crucial for developing personalized and effective approaches to cancer treatment. Further research in this area holds promise for improving patient outcomes and advancing the field of cancer immunotherapy. Cancer is a complex and heterogeneous disease that affects millions of people worldwide. The immune system plays a crucial role in recognizing and eliminating cancer cells, but tumors can develop various mechanisms to evade immune surveillance. Tumor-infiltrating lymphocytes (TILs) are a subset of immune cells that infiltrate the tumor microenvironment. In recent years, there has been growing interest in understanding the effects of TILs on the immune system and their potential implications for cancer treatment. This article explores the diverse roles of TILs and their impact on the immune system in the context of cancer[2].

Cancer is a complex and devastating disease that continues to pose a significant global health challenge. The immune system plays a vital role in recognizing and eliminating cancer cells, a process known as immune surveillance. However, tumors have evolved sophisticated mechanisms to evade immune detection and destruction, leading to disease progression. In recent years, the focus of cancer research has expanded to include the study of tumor-infiltrating lymphocytes (TILs) and their profound effects on the immune system within the tumor microenvironment[3].

Tumor-Infiltrating Lymphocytes (TILs)

TILs are lymphocytes, primarily T cells, that infiltrate the tumor site. They can be categorized into different subsets, including cytotoxic T cells, regulatory T cells, and natural killer cells. The presence and composition of TILs vary between tumor types and patients. TILs can exhibit an activated or exhausted phenotype, depending on the balance between anti-tumor effector functions and immune suppressive signals within the tumor microenvironment.

Prognostic value of TILs in cancer

The presence and density of TILs have been associated with improved prognosis in various cancers. High levels of TIL infiltration have been linked to increased overall survival rates and better response to immunotherapies. The presence of TILs, particularly cytotoxic T cells, signifies an ongoing immune response against the tumor and suggests that the immune system can recognize and target cancer cells. Therefore, TILs can serve as valuable prognostic biomarkers in cancer.

TILs and immune escape mechanisms

Despite the presence of TILs, tumors can still evade immune destruction. The tumor microenvironment is characterized by immune suppressive factors, such as regulatory T cells, myeloid-derived suppressor cells, and inhibitory immune checkpoints (e.g., PD-1/PD-L1). These factors can dampen the activity of TILs, leading to immune escape and disease progression. Understanding the mechanisms of immune suppression within the tumor microenvironment is crucial for developing strategies to overcome these barriers[4].

TILs and immunotherapy

Immunotherapies, such as immune checkpoint inhibitors, have revolutionized cancer treatment by unleashing the power of the immune system against tumors. TILs play a central role in the success of these therapies. Checkpoint inhibitors can reinvigorate exhausted TILs, restore their anti-tumor activity, and enhance tumor recognition. Furthermore, adoptive cell therapy, involving the infusion of ex vivo expanded TILs, has shown promising results in specific cancers.

Manipulating TILs for enhanced anti-tumor responses

Emerging research aims to manipulate TILs to optimize their anti-tumor activity. Approaches such as genetic engineering of TILs to express chimeric antigen receptors (CARs) or T cell receptor (TCR) specific for tumor antigens can enhance their targeting capabilities. Additionally, strategies to modulate the tumor microenvironment, such as depleting immune suppressive cells or blocking inhibitory signaling pathways, may improve TIL function and increase treatment efficacy.[5].

Conclusion

Tumor-infiltrating lymphocytes are essential players in the immune response against cancer. The presence and activity of TILs within the tumor microenvironment have significant implications for patient prognosis and response to immunotherapies. However, tumors employ diverse mechanisms to evade immune destruction, leading to disease progression. Harnessing the potential of TILs and overcoming immune escape mechanisms is a major focus of ongoing research. By understanding the complex interplay between TILs and the immune system, researchers and clinicians can develop novel strategies to enhance the anti-tumor immune response and improve patient outcomes. Ultimately, unraveling the effects of TILs on the immune system will pave the way for personalized and more effective approaches to cancer treatment.

References

  1. Giraldo NA, Becht E, Remark R, et al.The immune contexture of primary and metastatic human tumours.Curr Opin Immunol. 2014;27:8-15.

    2. Indexed at, Google Scholar, Cross Ref

  2. Snyder A, Chan TA.Immunogenic peptide discovery in cancer genomes.Curr Opin Genet Dev. 2015;30:7-16.

    3. Indexed at, Google Scholar, Cross Ref

  3. Mlecnik B, Tosolini M, Kirilovsky A, et al.Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.J Clin Oncol. 2011;29(6):610-8.

    4. Indexed at, Google Scholar, Cross Ref

  4. Britten CM, Janetzki S, Van der Burg SH, et al.Minimal information about T cell assays: The process of reaching the community of T cell immunologists in cancer and beyond.Cancer Immunol Immunother. 2011;60:15-22.

    5. Indexed at, Google Scholar,

  5. Groth C, Hu X, Weber R, et al.Immunosuppression mediated by myeloid-derived suppressor cells (MDSCs) during tumour progression.Br J Cancer. 2019;120(1):16-25.

    6. Indexed at, Google Scholar, Cross Ref

Get the App