Research in Clinical Dermatology

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Editorial - Research in Clinical Dermatology (2025) Volume 8, Issue 1

Cryotherapy in Dermatology: Mechanisms, Applications, and Clinical Outcomes

Cristina Chen *

Dermatology Department, University of Rio de Janeiro State, Brazil

*Corresponding Author:
Cristina Chen
Dermatology Department, University of Rio de Janeiro State, Brazil
E-mail: c.chen@icloud.com

Received: 2-Jan-2025, Manuscript No. aarcd-25-157506; Editor assigned: 4-Jan-2025, PreQC No. aarcd-25-157506 (PQ) Reviewed:17-Jan-2025, QC No. aarcd-25-157506Revised:24-Jan-2025, Manuscript No. aarcd-25-157506; Published:31-Jan-2025, DOI: 10.35841/aarcd- 8.1.245

Citation: Chen C. Cryotherapy in dermatology: Mechanisms, applications, and clinical outcomes. Res Clin Dermatol. 2025;8(1):245

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Introduction

Cryotherapy is a cornerstone technique in dermatology, widely used for the treatment of various skin conditions. This minimally invasive procedure involves the application of extreme cold to targeted tissues, resulting in controlled destruction of pathological cells. Liquid nitrogen, with a temperature of -196°C, is the most commonly employed cryogen, though carbon dioxide snow and nitrous oxide are also used in specific cases [1].

The primary mechanism of cryotherapy is the rapid freezing and thawing of tissues, leading to cellular injury and eventual necrosis. The process initiates with the formation of intracellular ice crystals, disrupting cellular membranes. Subsequent vascular stasis further impairs blood flow, causing ischemia and secondary cell death. The immune response may also play a role, as the release of antigens from destroyed cells can stimulate localized immune reactions, aiding in the clearance of treated lesions [2].

Cryotherapy is indicated for a wide range of dermatological conditions. It is most frequently used to treat benign skin lesions such as warts, seborrheic keratoses, and skin tags. In the context of premalignant conditions, actinic keratoses are effectively managed with cryotherapy, reducing the risk of progression to squamous cell carcinoma. Additionally, cryotherapy is a valuable tool for certain superficial skin cancers, including basal cell carcinoma, particularly in patients who are not candidates for surgical excision [3].

The procedure involves the application of liquid nitrogen either through a spray device or a cotton-tipped applicator. The duration and intensity of freezing depend on the lesion type, size, and location. For benign lesions, a shorter freeze time is often sufficient, while premalignant or malignant lesions may require a more aggressive approach with multiple freeze-thaw cycles. Careful technique and precise targeting are critical to avoid damage to surrounding healthy tissues [4].

Cryotherapy is favored for its simplicity, cost-effectiveness, and minimal downtime. It can be performed in outpatient settings without the need for anesthesia, making it an accessible option for patients. The procedure is quick, typically lasting only a few minutes, and patients can often return to their normal activities immediately afterward. Additionally, cryotherapy carries a low risk of systemic side effects, making it safe for most individuals [5].

Despite its advantages, cryotherapy has limitations. It is less effective for deeply invasive or large lesions, which may require alternative treatments such as surgery or systemic therapies. Common side effects include pain, blistering, and temporary hypopigmentation or hyperpigmentation. In rare cases, scarring or nerve damage can occur, particularly when treating lesions near sensitive areas such as the eyes or digits [6].

Numerous studies have demonstrated the efficacy of cryotherapy in managing a variety of skin conditions. For example, success rates for wart treatment range from 60% to 80%, depending on the number of sessions and lesion characteristics. Similarly, actinic keratoses respond well, with clearance rates exceeding 90% in many cases. The outcomes for superficial skin cancers are also promising, provided the lesions are carefully selected and treated [7].

Recent advancements in cryotherapy include the use of cryosurgery probes for more precise lesion targeting. These devices allow for controlled freezing at specific depths, expanding the applicability of cryotherapy to larger and more complex lesions. Additionally, there is growing interest in combining cryotherapy with other treatments, such as immunotherapies, to enhance therapeutic outcomes for certain skin cancers [8].

Appropriate patient selection is critical for the success of cryotherapy. Factors such as lesion type, size, and location, as well as patient age and skin type, must be considered. Patients should be counseled about the potential side effects and expected outcomes. For instance, individuals with darker skin tones may be more prone to pigmentary changes, which should be discussed prior to treatment [9].

Cryotherapy is also a popular choice for treating skin conditions in children, such as molluscum contagiosum and warts. Its non-invasive nature and quick application make it well-suited for pediatric patients, though the procedure may require modifications to minimize discomfort. In some cases, topical anesthetics or distraction techniques are employed to improve tolerance [10].

Conclusion

In conclusion, cryotherapy remains a versatile and valuable tool in dermatology. Its efficacy, safety profile, and ease of use make it a preferred option for various skin conditions. By understanding its mechanisms, indications, and potential risks, dermatologists can maximize the benefits of cryotherapy and continue to improve patient outcomes.

References

  1. Kotova TG, Tsybusov SN, Kochenov VI, e al. Application of cryogenic methods in skin diseases of different etiology. Dermatol Surg. 2018:47-86.

    2. Indexed at, Google Scholar, Cross Ref

  2. Mortada H, AlKhashan R, Daneshi K, et al. Exploring the role of cryotherapy in plastic surgery: Mechanisms, applications, and future directions. Eur J Plast Surg. 2025;48(1):3.

    3. Indexed at, Google Scholar, Cross Ref

  3. Abramovits W, Graham G, Har-Shai Y, et al. Dermatological cryosurgery and cryotherapy. Springer; 2016.

    4. Indexed at, Google Scholar, Cross Ref

  4. Sharma VK, Khandpur S. Guidelines for cryotherapy. Indian J Dermatol Venereol Leprol. 2009;75:90.

    5. Indexed at, Google Scholar

  5. Dzidek A, Piotrowska A. The use of cryotherapy in cosmetology and the influence of cryogenic temperatures on selected skin parameters—a review of the literature. Cosmetics. 2022;9(5):100.

    6. Indexed at, Google Scholar, Cross Ref

  6. Bayata S, Türel Ermertcan A. Thermotherapy in dermatology. Cutan Ocul Toxicol. 2012;31(3):235-40.

    7. Indexed at, Google Scholar, Cross Ref

  7. Gaitanis G, Bassukas ID. A review of Immunocryosurgery and a practical guide to its applications. Diseases. 2021;9(4):71.

    8. Indexed at, Google Scholar, Cross Ref

  8. Yeh JE, Wan MT, Alloo A, et al. Topical imiquimod and cryotherapy in combination with systemic immunotherapy in unresectable stage IIIC melanoma. JAAD Case Rep. 2022;27:162-6.

    9. Indexed at, Google Scholar, Cross Ref

  9. Mazor R, Mazor M, Dabiri AE, et al. New applications for cryotherapy. Mol Cell Biomech. 2020;17(2).

    10. Indexed at, Google Scholar, Cross Ref

  10. Lee EH, Lee HJ, Park KD, et al. Effect of a new cryotherapy device on an itchy sensation in patients with mild atopic dermatitis. J Cosmet Dermatol. 2021;20(9):2906-10.

    11. Indexed at, Google Scholar, Cross Ref

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