Asian Journal of Biomedical and Pharmaceutical Sciences

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Short Communication - Asian Journal of Biomedical and Pharmaceutical Sciences (2024) Volume 14, Issue 103

Creation of innovative medications for amyotrophic lateral sclerosis.

Zirul Awad *

Department of Psychiatry, University of Toronto, Canada

*Corresponding Author:

Department of Psychiatry
University of Toronto
Canada
E-mail: awad@zir.ul.ca

Received:27-Dec-2023, Manuscript No. AABPS-23-124852; Editor assigned:01-Jan-2024, PreQC No. AABPS-23-124852 (PQ); Reviewed:15-Jan-2024, QC No. AABPS-23-124852; Revised:22-Jan-2024, Manuscript No. AABPS-23-124852 (R); Published:29-Jan-2024, DOI:10.35841/ 14.103.219

Citation: Awad Z. Creation of innovative medications for amyotrophic lateral sclerosis. Asian J Biomed Pharm Sci. 2024;14(103):219

Introduction

setting, like a hospital, health system, or insurance program. It provides a list of medications that are permitted for usage in the facility, acting as a reference guide for medical professionals such as doctors, pharmacists, and other prescribers. Usually, a Pharmacy and Therapeutics (P&T) Committee made up of medical experts makes decisions about the choice, assessment, and administration of pharmaceuticals creates and updates the formulary [1].

Lou Gehrig's disease, often known as amyotrophic lateral sclerosis (ALS), is a progressive neurodegenerative illness that damages brain and spinal cord nerve cells and results in the loss of voluntary muscular control. Even though ALS is an uncommon disease, it has attracted a lot of attention because of the terrible effects it has on sufferers and the pressing need for efficient treatments. Because it is a complicated disease with multiple contributing factors—genetic, environmental, and cellular—ALS is difficult to understand. Since there is currently no known cure for ALS, the main goals of present treatments are to lessen symptoms and delay the course of the illness. Motor function in patients frequently declines unabatedly, resulting in severe disability and a lower quality of life. Due to the scarcity of available treatments, there is an urgent need for innovative therapeutic strategies that address the disease's fundamental causes [2].

Recent advances in genetic studies have illuminated the function of particular genes in the onset and course of ALS. The identification of several genetic variants linked to ALS has shed important light on the disease's processes. As a potential treatment option, gene therapy is now being investigated by researchers, who want to replace or alter damaged genes in order to stop or reduce the progression of ALS [3].

An important area of interest for ALS research is neuroprotection, or the maintenance of neuronal structure and function. Researchers are looking into novel drugs that help stave off the deterioration of motor neurons. The discovery of neurotrophic factors and small compounds with neuroprotective qualities has led to exciting advancements that raise the possibility of therapies that could change the course of ALS and improve patient outcomes. Research on stem cells is promising in the fight against ALS. The ability of stem cells to regenerate injured motor neurons, encourage neuroregeneration, and control ALS-related inflammatory reactions is being studied by scientists. The safety and effectiveness of stem cell therapies are being evaluated in clinical trials, providing a window into a future in which regenerative medicine will likely be integral to ALS treatment plans [4].

Novel chemicals and repurposed medications that may target particular pathways linked to the pathophysiology of ALS are being intensively investigated in pharmacological research. Researches on antioxidants, anti-inflammatory drugs, and compounds that can adjust abnormal cellular functions are all included in this. Pharmacotherapy for ALS has great promise in the discovery of new therapeutic targets and the creation of customized medications based on genetic profiles [5].

Conclusion

For those afflicted with this terrible illness, the development of novel ALS treatments offers a glimmer of hope. New therapeutic approaches for ALS are always being developed as scientists learn more about the genetic and molecular complexities of the disease. The field of ALS treatment could be completely changed by the continued dedication to cooperative research as well as improvements in genetic and pharmacological methods.

References

  1. Mueller S, Decker L, Menge S, et al. The fragile x protein family in amyotrophic lateral sclerosis. Molecu Neurobiolo. 2023;60(7):3898-910.

    2. Indexed at, Google Scholar, Cross Ref

  2. Wiesenfarth M, Günther K, Müller K, et al. Clinical and genetic features of amyotrophic lateral sclerosis patients with C9orf72 mutations. Brain Communica. 2023;5(2):fcad087.

    3. Indexed at, Google Scholar, Cross Ref

  3. Gwathmey KG, Corcia P, McDermott CJ, et al. Diagnostic delay in amyotrophic lateral sclerosis. Euro J Neurolo. 2023;30(9):2595-601.

    4. Indexed at, Google Scholar, Cross Ref

  4. Michels S, Kurz D, Rosenbohm A, et al. Association of blood lipids with onset and prognosis of amyotrophic lateral sclerosis: Results from the ALS Swabia registry. J Neurolo. 2023;270(6):3082-90.

    5. Indexed at, Google Scholar, Cross Ref

  5. Dubbioso R, Provitera V, Pacella D, et al. Autonomic dysfunction is associated with disease progression and survival in amyotrophic lateral sclerosis: A prospective longitudinal cohort study. J Neurolo. 2023:1-0.

    6. Indexed at, Google Scholar, Cross Ref

  6. Kao TH, Perry BJ. The current state and future directions of swallowing care in amyotrophic lateral sclerosis. Current Physi Medici Rehabili Repot . 2023:1-3.

    7. Indexed at, Google Scholar, Cross Ref

  7. Zhang J, Wang H. Current understanding of the association between Amyotrophic lateral sclerosis and frontotemporal dementia: Letter to Editor. Neurolo Lett. 2023;2(1):42-3.

    8. Indexed at, Google Scholar, Cross Ref

  8. Aslam A, Sarmad E, Nawaz A, et al. Brait fahn schwartz disease: A unique co-occurrence of parkinson’s disease and amyotrophic lateral sclerosis. Case Report 2023;15(1):207.

    9. Indexed at, Google Scholar, Cross Ref

  9. Wang H, Guan L, Deng M. Recent progress of the genetics of amyotrophic lateral sclerosis and challenges of gene therapy. Fronti Neurosci. 2023;17:1170996.

    10. Indexed at, Google Scholar, Cross Ref

  10. Zucchi E, Musazzi UM, Fedele G, et al. Effect of tauroursodeoxycholic acid on survival and safety in amyotrophic lateral sclerosis: a retrospective population-based cohort study. Clini Medic. 2023;65.

    11. Indexed at, Google Scholar, Cross Ref

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