Short Communication - Journal of Cancer Immunology & Therapy (2021) Volume 4, Issue 2
The Study on the relationship between tumor location, size and who grade in meningioma at tikur anbessa specilized hospital and mcm, addis ababa, ethiopia
Objective: The objective of this study is to look for the relationship between tumor size and location with
tumor grade in patients operated for intracranial meningioma at two neurosurgical training hospitals in Addis
Ababa. Methods: A retrospective clinical, neuroimaging and pathological data were collected from patients
undergoing meningioma resection at TikurAnbesa specialized teaching hospital and Myung sung Christian
medical college hospital, between Jan 2018 and Aug 2019. The largest tumor diameter on contrast-enhanced
MRI is used as tumor size. The location of a tumor is determined both from MRI and intraoperative findings
and classified into the skull base, non-skull base, and intraventricular. 2016 WHO CNS tumor classification is
used for tumor pathological grading. Univariate and multivariate logistic regression was done to investigate
the relationship between tumor size and location with tumor grade. Results:192 patients were included in the
study. Univariate logistic analysis was done if age, sex, tumor location, and size were significantly associated
with tumor grade. Age was not found to be a significant risk factor for atypical meningioma (P=0.29). Male
sex was a significant predictor of tumor grade (OR 3.44, 95% CI 1.41-8.39, P=0.007). Larger tumor size was
significantly associated with a meningioma being WHO grade II (P=0.028). Tumor location was found to be a
significant predictor of being atypical meningioma, predicting that convexity, PSM and falx meningiomas have
an atypical WHO grade (OR 10.625, 95% CI 3.03-37.2, P=0.000). Upon multivariate logistic analysis, only
tumor location was found to be independently associated with atypical meningioma (OR 6.93, 95% CI 1.828-
26.275, P= 0.004). Nonskull base meningiomas were associated with WHO grade II tumors. Conclusions: In
our series, tumor location is an independent risk factor for atypical meningioma but the size or gender is not.
Author(s): Temesgen G.