Review Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2017) Volume 7, Issue 60

Synthesis and Biological Evaluation of 2-[(3-Cyano-1-Oxo-4-(3,4,5-Trimethoxyphenyl)-1,2,3,4-Tetrahydronaphthalen-2-Yl) Thio] Benzoic Acid Derivatives

A series of 2-[(3-cyano-1-oxo-4-(3,4,5-trimethoxyphenyl)-1,2,3,4-tetrahydronaphthalen-2-yl) thio] benzoic acid have been synthesized with a significant stereo selectivity and improved yields in a single step by employing thiosalicylic acid in presence of Tetra-n-butylammonium bromide/methanol solvent system. The structures of the synthesized compounds were confirmed by spectral and elemental analysis data. The synthesized compounds were screened for their biological activity

Author(s): Chaitramallu, Devaraju Kesagodu, Ranjini

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