Research Article - Journal of RNA and Genomics (2022) Volume 0, Issue 0

Star Anise Essential Oil As An Enhancer And Restorer Of The Antibacterial Action For Certain Antibiotics Against Gram Positive Or Negative Multi-Drug Resistance Isolates.

To our knowledge, this is the first research on the use of Star Anise Essential Oil (SAEO) to activate and recover antibiotics that are now ineffective in medical therapy toward MDR bacteria. In the current study, the SAEO was investigated for its antibacterial properties and to evaluate the ability of Cephradine, Amoxicillin, Chloramphenicol and Tetracycline activity against both Gram-negative bacteria (Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae) or Gram-positive (Streptococcus pneumoniae and Staphylococcus aureus) MDR isolates. GC of the essential oil showed as major compounds the trans- anethole (90.07%). SAEO showed broad effectiveness against studied isolates. The antibacterial activity of SAEO was not changed by gamma irradiation at 10 and 30 kGy. Significant synergistic effects were noted with SAEO when it's associated with tested antibiotics. In combination with SAEO, a significant decrease in MICs values of all tested antibiotics was observed. Synergy was detected when SAEO/antibiotics combinations tested against MDR Gram-positive and Gram-negative bacteria with FICI ranging from 0.13 to 0.52 and from 0.26 to 0.56, respectively. The synergy in this study, using combinations of Star anise essential oil with antibiotics can enhance or restore the antibacterial activity of many antibiotics currently useless. Thus, SAEO could be an important and effective tool to be used individually or in combination with some therapeutic drugs (antibiotics) that are now ineffective to control bacterial MDR. Also, star anise contains shikimic acid (Tamiflu), which is a key ingredient in the pharmaceutical synthesis of the antiviral and anti-influenza drugs have a possible effect against thus; it may COVED-19.

Author(s): Abdel Khalek H, Mattar Z tt , Ibrahim M, Azam y

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