Research Article - Journal of Pharmaceutical Chemistry & Chemical Science (2021) Volume 5, Issue 3

Satisfactory access to attain pyrimidoquinoxaline 1,4-dioxide framework of prospective antitumor and antimicrobial activities.

We exploited the utilization of 2-amino-3-cyanoquinoxaline1,4-dioxide 1 to build new series of pyrimidoquinoxaline 1, 4-dioxide derivatives via multicomponent reactions of 1 with DMF-DMA, nbutyl amine, morpholine, Lawesson's reagent, benzoyl chloride. Furthermore, the new synthesized compounds were biologically evaluated for antitumor and antimicrobial activities

Author(s): Wafaa S Hamama*, Sara M Waly, Samy B Said, Hanafi H Zoorob

Abstract PDF