Research Article - Journal of RNA and Genomics (2022) Volume 0, Issue 0

Safety and efficacy assessment of combining chemoembolization with drug-eluting beads and conventional Tran's catheter arterial chemoembolization in patients with hepatocellular carcinoma: a single-centred experience.

Background and Aim: Many medical centers have applied TACE which include conventional transcatheter arterial chemoembolization (cTACE) and chemoembolization with drug-eluting beads (DEB-TACE) in their routine treatment. The dual benefit of DEB-TACE lies in their ability to enhance drug concentrations within the tumor while reducing the toxicity of the delivered payload but this procedure still has some limitations. This study reports results of combined DEB-TACE/cTACE procedure proposed by the Medical imaging & nuclear medicine center in Viet Duc hospital to improve the treatment outcome for Hepatocellular carcinoma. Method: The sample size included 32 HCC patients. Patients were treated with DEB-TACE and then cTACE 1 month after. Multi-detector computed tomography (MDCT) scans were performed 1 month after the DEB-TACE; 1, 3 and 6 months after the cTACE. Treatment responses were measured by MRECIST and necrosis degree. Results: Evaluating by MRECIST criteria, rate of complete response was 31.2%. The average degree of necrosis increased from 55.8% after DEB-TACE to 73.6% (p<0.05) after combined session (cTACE after DEB-TACE). The only side effect after 2 session of TACE was postembolization syndrome. Conclusions: This study showed that DEB-TACE following with cTACE may be considered as a safe and effective procedure for managing large liver tumor that requiring multiple session of embolization.

Author(s): Le Thanh Dzung*, Tran Viet Hung, Vu Thi Hoang LAN

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