+44 1400530055Review Article - Journal of RNA and Genomics (2018) Volume 14, Issue 1
Polycomb at the Crossroads: An Integrated Model with LncRNA- and Silencermediated Repression
Correct gene expression is achieved by controlling the balance of transcriptional activation and repression, the latter
including direct silencer-, Polycomb- and, more recently identified lncRNA- mediated repression. Here, we describe the
known and possible cross-talk mechanisms within and between these modes of repression. We discuss these mechanisms
within the framework of recruitment to as well as organization of the chromatin and propose possible research orientations
that would aim to further resolve the links within certain of these modes of repression, notably between Polycomb-,
lncRNA- and silencer-mediated silencing.
Author(s): Nadine Obier and Pierre Cauchy