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Research Article - Journal of Infectious Diseases and Medical Microbiology (2018) Volume 2, Issue 2
Plasmodium falciparum malaria and hospital associated visits among patients with hemoglobin variants attending general hospital Potiskum, Yobe State, Nigeria.
Malaria remains a major public health concern and a threat to the lives of people living in continuous malaria transmission regions of the world. While haemoglobin variants results in increased risks of morbidity due to the abnormality of haemoglobin molecules, the possession of these variants provides some degrees of acquired protections against malaria. This research was conducted to determine the common haemoglobinopathies and variation in parasitaemia among malaria infected persons in relation to hospital visits due to malaria in Potiskum Local Government Area, Yobe State, Nigeria. Venous blood was used to determine malaria parasitaemia and genotype of patients with fever related illnesses. Results obtained revealed patients with genotype AA having high parasite load, with 20 (32.79%) having moderate parasitaemia and 39 (63.93%) with low parasitaemia. However, due to low turnout of patients with sickle cell traits (SS), result obtained shows very low 18 (56.25%) to no parasitaemia 14 (43.75%) respectively. A total of 57 patients (35 (23.33%) males and 22 (14.67%) females have AS genotypes; 32 (18 (12%) males and 14 (9.33%) females with SS genotypes and 61 (31 (20.67%) males and 30(20%) females with AA genotypes. Certain mechanisms had been proved to proffer protections in patients with abnormal haemoglobin.
Author(s): Abdullahi M Daskum, Mohammed Ahmed