Research Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2016) Volume 6, Issue 59

Pharmacological activities palmatine alkaloid compound isolated from Guatteria friesiana prospects for new drug development

Medicinal plants have been used for thousands of years for the treatment of numerous diseases becoming an important source in the search for new drugs. Among the substances, palmatine, arising from natural sources, an alkaloid has been investigated with regard to their pharmacological actions and has demonstrated promising activity for the treatment of various diseases highlighting Alzheimer's disease (AD). The aim of this study was to verify the state of the art and technique on palmatine with emphasis on their pharmacological activity in vitro, in vivo and ex vivo which makes it promising in developing new drugs, primarily for the treatment of AD. 164 studies were found using the keywords "palmatine", "palmatine", "palmatine activity" and "activity palmatine". Patent deposit was not observed. The palmatine shown promising pharmacological activities, including: anti-inflammatory, anti-depressive, anti-pyretic, among others. Thus, it was observed that the alkaloid demonstrated some important pharmacological actions, including related to the therapy of neurodegenerative diseases.

Author(s): Soane Kaline Morais Chaves, Chistiane Mendes Feitosa, Felipe Pereira da Silva Santos and Joilane Alves Pereira Freire

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