Research Article - Current Pediatric Research (2024) Volume 28, Issue 7

Palatal mucormycosis in an immune-competent infant following dengue haemorrhagic fever: A rare disease entity, treated with a challenging course of IV liposomal amphotericin B for 270+ days, longest duration reported from Sri Lanka.

Background: Mucormycosis is an emerging global illness with significant morbidity and mortality. Causative fungi can spread through inhalation of sporangiospores or direct inoculation through damaged skin or mucosa in susceptible patients, especially those with impaired immune systems. Here we report a rare occurrence of the disease in an immunocompetent infant following dengue haemorrhagic fever, highlighting the treatment course which is the longest duration reported from Sri Lanka so far.

Case presentation: A 4-month-old infant was admitted to the medical Intensive Care Unit (ICU) after experiencing dengue haemorrhagic fever, which was complicated by multi-organ dysfunction and required intubation. After recovery, he was found to have a necrotic lesion in the palate, which was confirmed to be mucormycosis following biopsy. Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) scans showed erosions of the hard palate and involvement of the paranasal sinuses, orbital floor and soft palate without brain or eye lesions.

The child was started on Intravenous (IV) liposomal amphotericin B and required several debridement surgeries. Radiological studies showed persistent active bone lesions and antifungals were continued until radiological, mycological and clinical clearance was achieved. Intravenous amphotericin B was given for 270+ days required central lines and was complicated by venous thrombosis.

A palatal prosthesis was inserted until a definite palatal repair is done. The child is clinically well and thriving. Laboratory evaluations showed normal IgG and subclasses, IgA, IgM, and IgE levels, HIV testing was negative, Nitroblue Tetrazolium Test (NBT) was normal and metabolic screening was negative.

Conclusion: Though mucormycosis usually occur in children with immunosuppression or metabolic syndromes, it can occur in immunocompetent children, especially following a critical illness with high lactic acid levels, as in our case. It’s important to manage these children under multi-disciplinary care and complete treatment until there is evidence of radiological clearance to achieve better outcome.

Author(s): Hashan Pathiraja*, Rakitha Munasighe, Rasika Gunapala, Jerrad Fernando, Sandini Gunaratne, Chethana Pemasiri, Primali Jayasekera

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