+44-7360-538437- Biomedical Research (2012) Volume 23, Issue 1
Oxidative stress and antioxidative status in patients with alcoholic liver disease
The exact pro-oxidant and antioxidant status in alcoholic liver disease among the chronic alcoholics is still not clear. Alcoholic liver disease (ALD) & its complications are still one of the most frequent causes of death in both developing and developed counties. The present study was conducted to add a new insight to the question, whether ethanol induces oxidative stress, change in the level of antioxidant vitamins ascorbic acid & vitamins E (non- enzymatic antioxidant parameters), trace elements Zinc & Selenium & activities of antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) & catalase in erythrocytes. Study was performed in 40 patients with alcoholic liver disease (study subject) & compared to 40 age & sex matched healthy subject (controls). It was observed that they was a significant increase in MDA (Malondialdehyde), SOD, GPx and significant decrease in ascorbic acid, vitamin E, zinc, selenium & catalase activity in patients with alcoholic liver disease when compared to controls. The results of our study have shown higher free radical production, as evidenced by the increased MDA & decreased levels of ascorbic acid, vitamin E, selenium & catalase activity, supporting the hypothesis that they is increased oxidative stress in patients with ALD. The increased activities of antioxidant enzymes may be a compensatory regulatory response to increased oxidative stress. The decreased antioxidative status support the hypothesis that lipid peroxidation is an important causative factor in the pathogenesis of ALD. These data clearly indicates that, antioxidant mechanisms might be impaired in these patients. These findings also provide a therotical basis for the development of novel therapeutic strategies such as antioxidant supplementation.
Author(s): Ashok Shinde, Jayshree Ganu, Pankaja Naik, Annasaheb Sawant