Research Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2016) Volume 6, Issue 59

Optimization of Ibuprofen Carrying Poly-(3-Hydroxybutyrate) Extended Release Tablet by Central Composite Design

Context: Novel poly-(3-hydroxybutyrate)-based systems for controlled release of anti-inflammatory drug has been studied.

Methods: Ibuprofen diffusion processes determine the rate of the release at the early stages of the contact of the system with the environment (the first 6-8 h). The coefficient of the release diffusion of a drug depends on its nature, the thickness of the poly-(3-hydroxybutyrate) films containing the drug, the concentrations of Ibuprofen, and the molecular weight of the poly-(3-hydroxybutyrate). The use of central composite design (CCD) is used to map the optimal composition range for process parameters; this technique is mainly used to map the optimum ER Tablets. PHB base ER tablet of ibuprofen was prepared by direct compression technique and characterized by physicochemical parameters. The prepared tablets were evaluated physical properties hardness, friability, disintegration time and in vitro drug release.

Results and discussion: The drug release pattern, kinetic profiles as well as the low rate of IF release from the tablet is in satisfactory agreement with kinetics of weight loss measured in vitro for the PHB Tablet.

Conclusion: The results obtained are critical for developing systems of release of diverse drug, thus, enabling the attainment of the requisite physiological effects on tissues and organs of humans.

Author(s): Akshay Jirage, Khyyam Shaikh, Kate Vaishali, Payghan Santosh

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