Abstract - Research and Reports in Immunology (2021) Volume 4, Issue 7

Molecular dynamics simulations reveal a common conformation in the β chainconstant region in T cell receptor activation

The adaptive immune response is one of the most important systems of defense against pathogens. In this contest, the

ability of the CD8+ Cytotoxic T Lymphocytes (CTLs) to recognize a wide number of foreign antigens represents a strong

defense against diseases. The T cells response is regulated by T Cell Receptor (TCR) activation, which may occur following

the epitope recognition (p), mediated by the Major Histocompatibility Complex (MHC). Experimental studies have suggested

that conformational changes involving the constant region of the TCR α chain and of the CD3 complex are responsible for the

 

Author(s): Josephine Alba

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