Research Article - Journal of RNA and Genomics (2021) Volume 17, Issue 0

Lupeol favours GLUT4 translocation in gastrocnemius muscle through RAB10 and DOC2B expression in high fat diet induced rats.

Plant sources have been used for centuries as an effective therapeutic agent in treating many diseases. Lupeol is a triterpene plant sterol found in fruits and vegetables. Extensive research on lupeol revealed their pharmacological activities. Many in vitro and preclinical animal studies showed that lupeol has anti-inflammatory, anti-microbial, anti-proliferation, anti-invasive, anti-angiogenic and cholesterol lowering agents. This study is to demonstrate the insulin-sensitive regulation of GLUT4 and modulation of glucose uptake into the GLUT4 expressing cells. It also describes the regional and cellular expression of insulin sensitive glucose transporter, GLUT4 in gastrocnemius muscle. This study was aimed to evaluate the regional and cellular expression of the insulin sensitive glucose transporter, GLUT4 in gastrocnemius muscle and to assess the effect of lupeol expression in GLUT4. The effect of lupeol increases intake of glucose through R ab 10 and DOC 2B expression in gastrocnemius muscle. Our results along with the previously published reports, demonstrate that lupeol is involved at molecular level in glucose translocation. Our present findings provide evidence that lupeol can increase GLUT4 expression in diabetic animals. GLUT4 and Rab 10 mRNA expression were found to be increased by the lupeol and it was compared with standard drug metformin which shows significantly equal control rat (p<0.05). However, there was no significant change in the mRNA levels of DOC2B in all the groups.

Author(s): Sathya Kumar M, Gayathri R, V Vishnu Priya, J Selvaraj, Kavitha S

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