Review Article - Biomedical Research (2024) Volume 35, Issue 3

Into molecular mechanism of cardiac hypertrophy:Insights from "miRNA-sponging" non-coding RNAs.

Pathological cardiac hypertrophy is a maladaptive remodelling process in myocardium induced by variable clinical diseases and Heart Failure (HF) comes to the endpoint of myocardium hypertrophy. Non-coding RNAs (ncRNAs), including long non-coding RNA and circular RNA, were identified involving in cardiac hypertrophy remodelling. Competing endogenous RNA (CeRNA) network are the most accepted hypothesis and numerous studies has shown that lncRNA and circRNA can act as miRNA sponges which ultimately regulating the expression of downstream mRNA. Here we summarize the non-coding RNA with miRNA-sponging characteristics and the reported CerRNA networks, also the therapeutic value for siRNA drugs in CeRNA regulatory axis in the near future.

Author(s): Zhujun Shen*, Guangcheng Liu

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