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Short Communication - Journal of Pharmaceutical Chemistry & Chemical Science (2022) Volume 6, Issue 2
In A549 lung cells, pair formation and uptake via the polyamine transporter.
All cells contain the natural ketones are organic compounds putrescine, cadaverine, spermidine, and spermine. Anions, such as DNA and RNA, interact with these (poly) cations. This characteristic represents their most well-known direct physiological role in cellular functions: cell division, proliferation, and differentiation. The lungs, and specifically alveolar epithelial cells, appear to have a considerably more powerful polyamine absorption system than any other major organ. The active buildup of natural polyamines in the epithelium of the rat, hamster, rabbit, and human lungs has been examined in numerous mammalian species. Regardless of the polyamine or species analysed or the in vitro system employed, the uptake system's kinetic characteristics (MichaelisMenten constant and maximal uptake) are of the same order of magnitude. Polyamines are also accumulated by other pulmonary cells, but not to the same level as the epithelium. Although the lungs have separate uptake mechanisms for putrescine, spermidine, and spermine, neither the nature nor the cause for their existence is known.
Author(s): Vishaka Nagole*