Case Report - Immunology Case Reports (2023) Volume 6, Issue 4

Improving the understanding about Immune Profile before the HELLP Syndrome Onset: A Case Report

The term HELLP refers to the acronym characterized by Hemolysis, Elevated Liver enzymes and Low Platelets count. The aim of this study was to evaluate the immune profile of a pregnant woman that later developed HELLP syndrome in comparison to gestational age-matching healthy pregnant. We have determined multiple plasma biomarkers, including chemokines, pro-inflammatory/regulatory cytokines and growth factors in a pregnant woman (19th+4 week of gestation) 12 days before HELLP syndrome onset. An overproduction of CXCL10, CCL2, CCL11, CXCL8, IFN-? and IL-13, besides a pronounced deficiency of IL-6, G-CSF, IL-5, IL-10 and IL-12 was obtained in the studied pregnant woman comparing to controls. Our pioneer findings of pro-inflammatory increasing and insufficient regulatory mediators may support future strategies to clarify the early events associated with the HELLP syndrome pathophysiology. Furthermore, these data could be a powerful tool for providing disease early biomarkers, as well as perspectives for precise therapeutic intervention

Author(s): LMS Dusse*, PN Alpoim, AC Campi-Azevedo, FS Mendes, EM Lage, PG Teixeira, JGA Coelho-dos-Reis, A Teixeira-Carvalho and OA Martins-Filho

Abstract Full Text PDF