+1 (202) 780-3397- Asian Journal of Biomedical and Pharmaceutical Sciences (2015) Volume 5, Issue 42
Formulation Design and Development of Mucoadhesive Tablets of Cefixime Trihydrate
Mucoadhesive tablets of Cefixime trihydrate were prepared using Carbopol 940P, HPMC K15M and Polyox WSR 303 as a mucoadhesive polymers and β-cyclodextrin as a solubility enhancer. Nine formulations were developed using 32 factorial designs. Carbopol 940P is used as a primary polymer because of its excellent mucoadhesive property and secondary polymers like HPMC K15M & polyox were used. The formulations were tested for in-vitro drug release, mucoadhesive strength, swelling studies, residence time and surface pH. Formulation F3 showed maximum release of 23.03% in 7 hrs. Formulation F5 showed maximum mucoadhesive strength and force of adhesion. Formulation F9 showed maximum swelling index of 83.76%. Formulation F5 and F4 showed maximum residence time. All formulation follows the Koresmeyer-Peppas mode
Author(s): Ansari Afaque Raza Mehboob, Patil Ravikant Yashwantrao, Waghmode Chetan Satish, Shinde Ashalata Sudhakar