- Asian Journal of Biomedical and Pharmaceutical Sciences (2012) Volume 2, Issue 11

Formulation and Characterization of Novel Solid Dispersions of Hydrochlorothiazide by Solvent Evaporation Technique

The term solid dispersion refers to a group of solid products consisting of at least two different components, generally a hydrophilic matrix and a hydrophobic drug. In addition to bioavailability enhancement, much recent research on solid dispersion systems was directed towards the development of extended-release dosage forms. Knowledge about behavior of solid dispersions during preparation, storage and dissolution can help to tackle these problems. A thorough understanding of processes that occurs place on the molecular level is a prerequisite for rational and more efficient design of solid dispersions. However, development of solid dispersions has often been a trial-and-error approach. Solid dispersion prepared by solvent evaporation method were subjected to x ray diffraction study, dissolution study, In the present study, a 32 full factorial design was employed containing 2 factors evaluated at 3 levels and experimental trials were performed at all 9 possible combinations. Two independent variables selected were HPMC E5 and PVP K30. The objective achieved and these findings suggested that the above-mentioned technique can be employed successfully for improvement of solubility profile and stability of Solid dispersions of poorly water soluble drugs.

Author(s): Abhay N. Padalkar, Sadhana R. Shahi, Abhijit G. Kale, Mahesh Thube, Varsha A .Padalkar

Abstract PDF