Opinion Article - Journal of Genetics and Molecular Biology (2021) Volume 5, Issue 5

Evidence of gene selection by ivermectin in the Onchocerca volvulus 2-tubulin gene polymorphism in the Mbonge sub-division of Cameroon.

Ivermectin (IVM) is still the sole safe medicine for mass onchocerciasis control, and its efficacy is critical to the success of control programmes. However, relying on a single treatment for decades could be problematic due to the development of IVM resistance, as seen in cattle nematode infections and canine filarial heartworm. Drug resistance is a genetic phenomenon that results from changes in the parasite population's genetic profile, which can be interpreted as selection for specific gene variants. Author(s): Fleur Delacour

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