Short Communication - Journal of Child and Adolescent Health (2022) Volume 6, Issue 3
Evaluating new born child antibody reactions in childhood immunization
with immune system clutters
New-borns and infants are highly susceptible to infectious diseases, resulting in high mortality
and morbidity, particularly in resource-poor settings. Many vaccines require several booster
doses, resulting in an extensive vaccine schedule, and yet there is still inadequate protection
from some of these diseases. This is partly due to the immaturity of the neonate and infant
immune system. Little is known about the specific modifications to immunological assessment
protocols in early life but increasing knowledge of infant immunology has helped provide better
recommendations for assessing these responses. Since most new vaccines will eventually be
deployed in low-income settings such as Africa, the logistics and resources of assessing immunity
in such settings also need to be understood. In this article, we will review immunity to vaccines
in early life, discuss the many challenges associated with assessing immunogenicity and provide
practical tips. Author(s): David Walker
Abstract
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