Research Article - Journal of RNA and Genomics (2022) Volume 0, Issue 0

Effect of Melastoma Malabathricum L Extract on Melanine in Rats Exposed Uv Radiation.

UV radiation can reaches the earth's surface that can cause burning of the skin with signs such as redness of the skin (erythema), pain, blistering and peeling of the skin. UV radiation also triggers the emergence of oxidant. One of the oxidant compounds produced by UV light is hydrogen peroxide. Hydrogen peroxide can trigger the formation of tyrosine and tyrosine causes the appearance of melanine. So it is necessary to have antioxidants to overcome UV radiation. One of the plants that has antioxidant activity is M. malabathricum L. Blossoms M. malabathricum L has greater antioxidant activity than bud flowers with an IC50 value of 6.9 ppm. The purpose of this study was to analyze the protective activity against UV rays of sunscreen lotion with ethanol extract of M. malabathricum L (LSFM) flowers as seen from the erythema index, melanin, SPF value, thyrosine and skin histology of rats exposed to UV-C light. The results showed lotion extract M. malabathricum L has sun protection activity with decrease level of eritema, melanin dan hydrogen peroxide.

Author(s): Isnaini, Ika K Oktaviyanti, Eko Soehartono, Khairunida

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