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Research Article - Allied Journal of Medical Research (2021) Volume 5, Issue 2
Development of niacinamide and calendula oil anti-acne gel using carrageenans as gelling agents.
The objective of this research work was to formulate an anti-acne gel consisting carrageenan as gelling agent, Niacinamide and calendula oil as acne controlling agents. In this present work, effect of calendula oil alone was ascertained in treatment of acne, in addition to comparison of anti acne properties of niacinamide and calendula oil combinatioin. Six formulations of gels were formulated and evaluated. Out of 6 formulations, the first three formulations (F1, F2 and F3) were carried out using niacinamide as active substance and carrageenan as gelling agent, the other three formulation (F4, F5 and F6) were carried out using niacinamide and calendula oil in combination as active substances and carrageenan as gelling agent. FTIR studies confirmed that there was no distinguishable physical or chemical interaction between drug and excipients used for this study of anti acne gel formulations. All formulations were evaluated for general appearance, viscosity, pH, drug content, spreadability, invitro diffusion studies and anti microbial studies. Results showed, using a combination of calendula oil and niacinamide proved effective treatment of acne than calendula oil used alone or niacinamide used alone. The prepared anti acne gels were characterized by Fourier transform infrared (FT-IR) spectroscopy, In – Vitro diffusion profile and anti microbial studies. All the gel formulations showed more than 60 percentage drug release within 180 minutes, which was far better when compared to drug release profile of pure drug. By this study, it can be concluded that calendula oil in combination with acne treating drugs can be used as a conjunction in the formulation of gels. The anti microbial spectra of the drug could be improved by this methodology by more than 1.5 times due to improved permeability when compared to pure drug. This combination of calendula oil and niacinamide, using carrageenan as gelling agent can be further exploited for the successful treatment of acne.
Author(s): Sravya Maddukuri, Lakshmi Devi G, Samyuktha Metta, KS Murali Krishna