Research Article - Journal of RNA and Genomics (2022) Volume 0, Issue 0

Clinical Benefits of High And Low Dose Antivenom Serum 2 For The Treatment Of Snakebite A Meta-Analysis.

UV radiation Venomous snake bite is considered to be a kind of critical illness, which requires immediate emergency measures to ensure the life safety of the patients. Objective: To compare and analyze the clinical effect of high and low dose of antivenom serum on patients. Methods: Seven databases (PubMed, EMBASE, Cochrane, web of science, Wanfang, HowNet, VIP) were searched systematically to include the published papers on the effect of different doses of antivenom serum on clinical benefits of patients with randomized controlled trials. The analysis indexes included: cure rate, allergic reaction, length of hospital stay, patients' acceptance, liver and kidney function indexes (alt, BUN), myocardial enzyme indexes (AST, LDH, CK, CK-MB), coagulation indexes (PT, TT). Results: A total of 10 references were included. Among 10 randomized controlled trials, the high-dose antivenom serum group was the experimental group, and the low-dose antivenom serum group was the control group, 1856 in the experimental group and 656 in the control group. The results of metaanalysis showed that: (1) There were significant differences in cure rate, allergic reaction, length of stay, patients' acceptance, ALT level, adverse reactions, adverse reactions, hospitalization time, bun, and Pt. (2) There was no significant difference in AST, LDH, CK, CK-MB, and TT. Conclusion: The dosage of antivenom serum has a certain influence on the treatment of patients bitten by venomous snakes, and this study can be used as a clinical reference.

Author(s): Zhicheng Zhong, Zhanzheng Yang, Rong Liu, Rongde Lai, Liangbo Zeng, Ping Yan, Min Jiang, Guibin Chen

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