+1 (202) 780-3397- Asian Journal of Biomedical and Pharmaceutical Sciences (2015) Volume 5, Issue 48
Celecoxib Bionanocomposite: Investigation of the effect of microwave irradiation using natural solubilizer
The main objective of present work was to enhance the solubility and improve the rate of dissolution of drug Celecoxib which is poorly water soluble as it belongs to BCS class II. Enhancement of solubility was be achieved by converting the BCS Class II drugs into bionanocomposites (BNCs) by using natural carriers and Microwave assisted Fusion method were employed, which ultimately leads to enhance the bioavailability of drug entity. Bionanocomposites (BNCs) were prepared using microwave assisted synthesis fusion method, where the drug entities were fused with natural carriers such as acacia, gelatin and ghatti gum. Selection of carriers was done based on their wetting and surfactant properties. The FTIR, DSC studies reveals that there was no any interaction between Celecoxib and Natural carriers. Solubility dissolution studies were carried out to investigate the solubilityenhancing property of the BNC. Mixture dissolution and in-vitro dissolution of prepared Celecoxib’s BNCs were characterized through DSC, SEM XRD and FTIR. From the study it was found that, the designed and developed nine batches of BNCs among which fourth batch was with Celecoxib: Acacia (1:4) shown the acceptable solubility i.e. 0.0113 mg/ml and its % drug release was found to be 91.58%. The four Batches of Immediate release tablet was prepared and evaluated using official methods viz; weight variation, Content uniformity, in-vitro dissolution. BNCs of Celecoxib prepared with Acacia provides significant enhancement in solubility and highlights its use in solubility and dissolution enhancement.
Author(s): Mahesh R. Bhat, Patil Ashish, Batra A.K, Chimkode R.M, Payghan Santosh