Research Article - Asian Journal of Biomedical and Pharmaceutical Sciences (2021) Volume 11, Issue 82

Association of NKX2-1 rs944289 SNP with DTC in sudanese population

The majority of malignant thyroid tumors derive from follicular epithelial cells. The Differentiated Thyroid Cancers (DTC) are papillary (PTC: 85% of cases) and follicular (FTC: 10% of cases) subtypes, and their etiology is still not well characterized. The transformation of normal into malignant tissue is a multifactorial process involving genetic and environmental factors such as radiation exposure. Some environmental factors such as hepatitis C infection or late and multiple pregnancies have been suggested as risk factors, but they have not been confirmed. Moreover, genetic components-for example proto-oncogenes, which encode Receptor Tyrosine Kinases (RET) and small GT Pases (RAS)-may contribute to thyroid cancer formation in familial syndromes. However, none of these factors is thyroid specific, and therefore the identification of additional candidate genes is important for a better understanding of the pathogenesis of thyroid cancer.

Author(s): Fahmi Mahdi*, Nassr Eldin

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